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首页> 外文会议>Conference on Optical Coherence tomography and coherence domain optical methods in biomedicine XXI >Collagen birefringence assessment in heart chordae tendineae through PS-OCT
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Collagen birefringence assessment in heart chordae tendineae through PS-OCT

机译：Chordae Sentineae通过PS-OCT的胶原蛋白双折射评估

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Degenerative mitral regurgitation is a serious and frequent human heart valve disease. Malfunctioning of this valve brings the left-sided heart through a significant increase of pressure and volume overload. Severe degenerative mitral incompetence generally requires surgical repair or valve replacement with a bioprosthesis or mechanical heart valve. Degenerative disease affects the leaflets or/and the chordae tendineae, which link both leaflets to the papillary muscles. During mitral valve surgical repair, reconstruction of the valve leaflets, annulus and chordae are provided to prevent postoperative recurrence of valve regurgitation. The operative evaluation of the diseased and apparently normal chordae tendineae mainly depends of the surgeon's experience, without any other objective diagnosis tool. In this work, PS-OCT (Polarization Sensitive-Optical Coherence Tomography) is applied for the first time to evaluate the pathological condition of human chordae coming from the mitral valve. It consists on a prospective study to test the viability of this technique for the evaluation of the collagen core of chords. This core presents a strong birefringence due to the longitudinal and organized arrangement of its collagen bundles. Different densities and organizations of the collagen core translate into different birefringence indicators whose measurement become an objective marker of the core structure. Ex-vivo mitral degenerative chordae tendineae have been analyzed with PS-OCT. Intensity OCT is used to obtain complementary morphological information of the chords. Birefringence results correlate with the previously reported values for human tendinous tissue.
机译：退行性二尖瓣反流是一种严重和频繁的人类心脏瓣膜病。该阀的故障通过大量增加的压力和体积过载来带来左侧心脏。严重退化的二尖瓣无能通常需要用生物假体或机械心瓣进行手术修复或瓣膜。退行性疾病影响小叶或/和Chordae肌腱，其将叶片链接到乳头肌肉中。在二尖瓣手术修复过程中，提供了阀门传单，环形和腱瓣的重建，以防止阀门反流的术后复发。患病和显然正常的Chordae Senteae的手术评价主要取决于外科医生的经验，没有任何其他客观诊断工具。在这项工作中，第一次应用PS-OCT（偏振敏感 - 光学相干断层扫描），以评估来自二尖瓣的人Chordae的病理状况。它包括测试该技术的可行性来评估和弦的核心核心的可行性。由于其胶原束的纵向和有组织的布置，该核心具有强大的双折射。胶原芯的不同密度和组织转化为不同的双折射指示，其测量成为核心结构的客观标记。已经用PS-OCT分析了前体内二尖瓣退化性Chordae培养赛。强度OCT用于获得和弦的互补形态信息。双折射结果与先前报道的人腹腹膜组织的值相关联。

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