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首页> 外文会议>Conference on Optical Coherence tomography and coherence domain optical methods in biomedicine XXI >Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography
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Multi-volumetric registration and mosaicking using swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography

机译：使用扫描源光谱编码扫描激光眼镜和光学相干断层扫描的多容量登记和摩托车

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Ophthalmic diagnostic imaging using optical coherence tomography (OCT) is limited by bulk eye motions and a fundamental trade-off between field-of-view (FOV) and sampling density. Here, we introduced a novel multi -volumetric registration and mosaicking method using our previously described multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and OCT (SS-SESLO-OCT) system. Our SS-SESLO-OCT acquires an entire en face fundus SESLO image simultaneously with every OCT cross-section at 200 frames-per-second. In vivo human retinal imaging was performed in a healthy volunteer, and three volumetric datasets were acquired with the volunteer moving freely and re-fixating between each acquisition. In post-processing, SESLO frames were used to estimate en face rotational and translational motions by registering every frame in all three volumetric datasets to the first frame in the first volume. OCT cross-sections were contrast-normalized and registered axially and rotationally across all volumes. Rotational and translational motions calculated from SESLO frames were applied to corresponding OCT B-scans to compensate for inter-and intra-B-scan bulk motions, and the three registered volumes were combined into a single interpolated multi-volumetric mosaic. Using complementary information from SESLO and OCT over serially acquired volumes, we demonstrated multi-volumetric registration and mosaicking to recover regions of missing data resulting from blinks, saccades, and ocular drifts. We believe our registration method can be directly applied for multi-volumetric motion compensation, averaging, widefield mosaicking, and vascular mapping with potential applications in ophthalmic clinical diagnostics, handheld imaging, and intraoperative guidance.
机译：使用光学相干断层扫描（OCT）的眼科诊断成像通过本体眼运动和场的视场（FOV）之间的基本折衷和采样密度的限制。在这里，我们引入了一个新的多-volumetric登记并使用我们的先前所描述的多模式扫描源光谱方面经编码的扫描激光检眼镜及OCT（SS-SESLO-OCT）系统镶嵌方法。我们的SS-SESLO-OCT获取整个连接面眼底SESLO图像以200帧每秒每OCT截面同时。体内人视网膜成像是在健康志愿者进行的，和三个立体数据集用志愿者自由移动和每个采集之间重新固定获得的。在后处理，SESLO帧被用来通过在所有三个立体数据集每帧注册在所述第一体积的第一帧的连接面的旋转和平移运动估算。 OCT横截面是对比标准化和所有卷轴向和旋转登记。转动和从SESLO帧计算的平移运动被应用到相应的OCT B-扫描，以补偿帧间和-B帧内扫描散装运动，和三个注册体积组合成单个内插多容积镶嵌。使用来自SESLO和OCT过串联体积取得的补充信息，我们证明多容积登记和镶嵌以恢复丢失的从闪烁，扫视和眼漂移产生的数据的区域。我们相信可直接应用于多容积运动补偿，平均，宽视场镶嵌，并用在眼科临床诊断潜在的应用，手持式成像血管映射，和术指导我们的配准方法。

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