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首页> 外文会议>Conference on Optical Coherence tomography and coherence domain optical methods in biomedicine XXI >Model-independent quantification of soft tissue viscoelasticity with dynamic optical coherence elastography
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Model-independent quantification of soft tissue viscoelasticity with dynamic optical coherence elastography

机译：具有动态光学相干弹性术的软组织粘弹性的模型无关量化

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Mechanical properties of cells and tissues play an important role in governing both normal and diseased biological processes. Recent findings in mechanobiology have demonstrated that viscosity, independent of elasticity, of extracellular matrix (ECM) can alter cellular behaviors. To obtain a comprehensive understanding of the mechanical properties of viscoelastic biological tissues for biomedical applications and mechanobiology research, both the elasticity and the viscosity must be characterized. Although optical coherence elastography (OCE) has emerged as a promising tool for probing the mechanical properties of biological tissues, quantitative OCE methods have mostly been limited to elasticity reconstruction or relied on the use of a presumed mechanical model, which may or may not adequately describe the response of a given tissue type. We present the first experimental demonstration of a mechanical model-independent reconstruction of complex shear modulus from direct measurement of surface wave propagation in viscoelastic media with dynamic acoustic radiation force (ARF)-OCE. Our results suggest that elasticity imaging based on shear wave speed alone could overlook potentially significant variations in the viscoelastic properties of biological tissues.
机译：细胞和组织的力学性质在治疗正常和患病的生物过程中发挥着重要作用。最近在力学学中的发现表明，与细胞外基质（ECM）的弹性无关的粘度可以改变细胞行为。为了综合了解粘弹性生物组织的机械性能，用于生物医学应用和力学学研究，必须表征弹性和粘度。尽管光学相干弹性术（OCE）作为探测生物组织的机械性能的有前途的工具，但定量的OCE方法主要限于弹性重建或依赖于使用推定的机械模型，这可能或可能不会充分描述给定组织类型的响应。我们在具有动态声学辐射力（ARF）的粘弹性介质中的表面波传播的直接测量，介绍了对复杂剪切模量的机械模型 - 独立重建的第一个实验证明。我们的研究结果表明，基于剪切波速的弹性成像可以忽略生物组织的粘弹性的潜在显着变化。

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