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首页> 外文会议>Conference on Optical Coherence tomography and coherence domain optical methods in biomedicine XXI >Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz
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Multimodal swept-source spectrally encoded scanning laser ophthalmoscopy and optical coherence tomography at 400 kHz

机译：多模式扫描源光谱编码扫描激光眼科和光学相干断层扫描，400 kHz

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Multimodal imaging systems that combine scanning laser ophthalmoscopy (SLO) and optical coherence tomography (OCT) have demonstrated the utility of concurrent en face and volumetric imaging for aiming, eye tracking, bulk motion compensation, mosaicking, and contrast enhancement. However, this additional functionality trades off with increased system complexity and cost because both SLO and OCT generally require dedicated light sources, galvanometer scanners, relay and imaging optics, detectors, and control and digitization electronics. We previously demonstrated multimodal ophthalmic imaging using swept-source spectrally encoded SLO and OCT (SS-SESLO-OCT). Here, we present system enhancements and a new optical design that increase our SS-SESLO-OCT data throughput by >7x and field-of-view (FOV) by >4x. A 200 kHz 1060 nm Axsun swept-source was optically buffered to 400 kHz sweep-rate, and SESLO and OCT were simultaneously digitized on dual input channels of a 4 GS/s digitizer at 1.2 GS/s per channel using a custom k-clock. We show in vivo human imaging of the anterior segment out to the limbus and retinal fundus over a >40° FOV. In addition, nine overlapping volumetric SS-SESLO-OCT volumes were acquired under video-rate SESLO preview and guidance. In post-processing, all nine SESLO images and en face projections of the corresponding OCT volumes were mosaicked to show widefield multimodal fundus imaging with a >80° FOV. Concurrent multimodal SS-SESLO-OCT may have applications in clinical diagnostic imaging by enabling aiming, image registration, and multi-field mosaicking and benefit intraoperative imaging by allowing for real-time surgical feedback, instrument tracking, and overlays of computationally extracted image-based surrogate biomarkers of disease.
机译：组合扫描激光眼科（SLO）和光学相干断层扫描（OCT）的多峰成像系统已经证明了并发en面部和体积成像用于瞄准，眼睛跟踪，散装运动补偿，镶嵌和对比度增强。然而，这种额外的功能折衷具有增加的系统复杂性和成本，因为SLO和OCT二者通常需要专用的光源，振镜扫描仪，中继和成像光学器件，检测器，和控制和数字化电子。我们之前展示了使用扫描源光谱编码的SLO和OCT（SS-SESLO-OCT）的多模式眼科成像。在这里，我们呈现系统增强功能和新的光学设计，通过> 4X将SS-SESLO-OCT数据吞吐量增加> 7倍和视野（FOV）。将200kHz 1060nm Axsun Shept-Source光学缓冲到400 kHz扫描速率，并且SESLO和OCT在每通道的1.2 GS / S的双输入通道上同时数字化，使用自定义k时钟在1.2 GS / s的1.2 GS / s的情况下。我们以60°FOV的悬浮在林斯和视网膜眼底的前段的体内人体成像。此外，在视频速率SESLO预览和指导下获得了九个重叠体积SS-SESLO-OCT卷。在后处理中，所有九个SESLO图像和相应的OCT容积的面部投影都被镶嵌地显示出宽场多模态眼底成像，具有> 80°FOV。通过允许实时手术反馈，仪器跟踪和基于计算的图像的基于图像的基于图像的实时手术反馈，仪器跟踪和覆盖，可以通过启用瞄准，图像登记和多场摩托车和益处术中成像来具有临床诊断成像中的应用。孕妇生物标志物。

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