• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on advances in optics for biotechnology, medicine and surgery XV >BEDSIDE MEASUREMENT OF CEREBRAL HEMODYNAMIC BIOMARKERS WITH FAST DIFFUSE CORRELATION SPECTROSCOPY
【24h】

BEDSIDE MEASUREMENT OF CEREBRAL HEMODYNAMIC BIOMARKERS WITH FAST DIFFUSE CORRELATION SPECTROSCOPY

机译：具有快速漫射相关光谱的脑血流动力学生物标志物的床头旁

获取原文
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The objective assessment and characterization of cerebral tissue health at the bedside is a difficult but highly significant problem in the acute care of strokes and other brain injuries. Observational limitations of current technologies, which are better suited for radiological snapshots rather than continuous monitoring of cerebrovascular health, limit bedside optimization/augmentation of care to subjective judgements of observed neurological deficits. In recent years, Diffuse Correlation Spectroscopy (DCS) has proven to be an increasingly popular non-invasive optical technique to solve this technological gap by directly measuring and monitoring deep tissue blood flow. Here, we highlight DCS's utility as a clinical bedside monitor of acute CBF changes in patients affected with ischemic stroke. In addition, we highlight the development and application of new 'fast' DCS instrument that uses conventional DCS sources/detectors, and optimized software computations to measure blood flow 'waveforms' at measurement rates of 50-100 Hz. A direct consequence of this new CBF data type is the ability to characterize potentially chronic biomarkers of cerebral tissue health at the bedside. First, we employ the fast-DCS instrumentation to measure cerebral autoregulation (CVAR) dynamics. Cerebral autoregulation, which is impaired in the injured brain, refers to the mechanism by which cerebral blood flow (CBF) is maintained during fluctuations in blood pressure. We derive an index of autoregulation by measuring the rates of decrease (and recovery) of blood flow and blood pressure resulting from a sudden, induced change in systemic blood pressure (i.e., bilateral thigh cuff deflation). Second, we utilized pulsatile blood flow to estimate the critical closing pressure (CrCP) of cerebral microvasculature, i.e., the arterial blood pressure at which CBF approaches zero. Notably, CrCP can be an indicator of intracranial pressure and vasomotor tone. In both cases, our pilot experiments in healthy volunteers show that DCS measured rates of micro-vascular regulation and CrCP are in good agreement with comparable metrics derived with transcranial Doppler ultrasound.
机译：床边脑组织健康的客观评估和表征是急性护理和其他脑损伤的难以但高度重大问题。目前技术的观测限制，更适合放射性快照而不是对脑血管健康的连续监测，限制床边优化/扩大对观察到的神经缺陷的主观判断。近年来，漫反射谱（DCS）已被证明是一种越来越受欢迎的非侵入性光学技术，通过直接测量和监测深层组织血流来解决这种技术差距。在这里，我们突出了DCS的效用作为缺血性卒中影响的患者急性CBF变化的临床床位监测。此外，我们突出了新的“快速”DCS仪器的开发和应用，该仪器使用传统的DCS源/探测器，并优化的软​​件计算，以测量50-100 Hz的测量速率下的血流“波形”。这种新的CBF数据类型的直接后果是能够在床边表征脑组织健康的潜在慢性生物标志物。首先，我们采用FAST-DCS仪器来测量脑自动调节（CVAR）动态。在受伤的大脑中受损的脑自动调节是指在血压波动期间维持脑血流（CBF）的机制。通过测量血液流动和突然引起的系统性血压（即双侧大腿袖带通缩）产生的血流和血压的降低（和恢复）的速度来衍生自动化指数。其次，我们利用脉动血流来估计脑微血管系统的临界闭合压力（CRCP），即CBF接近零的动脉血压。值得注意的是，CRCP可以是颅内压和血管运动调的指标。在这两种情况下，我们在健康志愿者中的试验实验表明，DCS测量的微血管调节和CRCP率与衍生经颅多普勒超声的可比度量吻合良好。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号