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首页> 外文会议>Conference on ophthalmic technologies XXVII >Investigation of retinal microstructure in healthy eyes and dry age-related macular degeneration using a combined AO-OCT-SLO system
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Investigation of retinal microstructure in healthy eyes and dry age-related macular degeneration using a combined AO-OCT-SLO system

机译：使用组合AO-OCT-SLO系统调查健康眼中健康眼和干龄相关性黄斑变性的研究

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Combined adaptive optics (AO) optical coherence tomography (OCT) scanning laser ophthalmoscopy (SLO) imaging allows simultaneous en face and cross sectional views of the retina. We describe improvements to our AO-OCT-SLO system and highlight its resolution capability and clinical utility by presenting results from 3 control and 4 dry age-related macular degeneration (AMD) subjects. From a group of subjects with healthy eyes, OCT A-scans were grouped as originating from cones or rods and were averaged. The resulting reflectance profiles were then used to identify the location of cone and rod segments. Results for rods and cones were compared, with the focus on inner segment (IS) and outer segment (OS) structures and where these cells embed into the retinal pigment epithelium (RPE). In the AMD patients, cone IS and OS lengths were measured over and around drusen for two retinal regions (fovea-2° and 2°-4°), and those results were correlated to drusen height. For the fovea-2° region, the drusen height that caused statistically significant shortening of cone ISL and OSL compared to the unaffected adjacent area were 40 urn and 50 μm respectively (p = 0.009, and p < 0.001, respectively). For the 2°-4° region, the equivalent drusen heights that caused significant shortening of segment length were 60 μm for IS (p = 0.017) and 80 μm for OS (p < 0.001).
机译：组合自适应光学（AO）光学相干断层扫描（OCT）扫描激光眼压镜（SLO）成像允许同时展望视网膜和横截面视图。我们描述了对我们的AO-OCT-SLO系统的改进，并通过呈现来自3个对照和4个干龄相关的黄斑变性（AMD）受试者的结果来突出其分辨率和临床效用。从一群健康的眼睛，OCT A扫描被分组为源自锥体或杆，并平均。然后使用得到的反射曲线识别锥形和杆段的位置。比较杆和锥体的结果，聚焦在内部区段（是）和外部区段（OS）结构以及将这些细胞嵌入视网膜色素上皮（RPE）中。在AMD患者中，锥体是并且OS长度在两个视网膜区域（FoVEA-2°和2°-4°）上方和博客周围测量，结果与司令高度相关。对于FoVEA-2°区域，与未受影响的相邻区域相比，锥体ISL和OSL统计上显着缩短的玻璃疣高度分别为40μM，分别为50μm（P = 0.009，P <0.001）。对于2°-4°区域，导致段长度的显着缩短的等效疣高度为60μm（p = 0.017）和80μm的OS（p <0.001）。

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