Characterisation of a Novel Transmission Raman Spectroscopy Platform for Non-Invasive Detection of Breast Micro-Calcifications

机译：用于乳房微钙的非侵入性检测的新型传输拉曼光谱平台的表征

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Our work focuses on the development of a medical Raman spectroscopy based platform to non-invasively detect and determine in-vivo molecular information deep inside biological tissues by monitoring the chemical composition of breast calcifications. The ultimate goal is to replace a needle biopsy which typically follows the detection of an abnormality in mammographic images. Here we report the non-invasive detection of calcium oxalate monohydrate in tissue through 40 mm of phantom tissues using our recently developed advanced Raman instrument complementing our previous detection of calcium hydroxyapatite through this thickness of tissue. The ability to detect these two key types of calcifications opens avenues for the development of non-invasive in-vivo breast cancer diagnostic tool in the future.

机译：我们的工作侧重于通过监测乳房钙化的化学成分，对基于医疗拉曼光谱的平台进行非侵入性地检测和确定体内分子信息。最终目标是替代针活检，其通常遵循乳房X线图中的异常。在这里，我们通过我们最近开发的先进拉曼仪器通过这种组织厚度地检测了我们之前的羟基磷灰石的预先检测羟基磷灰石的含量，通过40mm的幽灵组织报告了通过40mm的幽灵组织的非侵入性检测。检测这两种关键类型的钙化的能力为未来开辟了非侵入性体内乳腺癌诊断工具的途径。

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《SPIE Conference on Biomedical Vibrational Spectroscopy: Advances in Research and Industry》|2018年|1 v. (various pagings) :|共5页
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Adrian Ghita; Pavel Matousek; Nick Stone;
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中图分类 N-532;
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Raman spectroscopy; breast cancer; hydroxyapatite; calcium oxalate;

机译：拉曼光谱;乳腺癌;羟基磷灰石;草酸钙;

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1. Urine surface-enhanced Raman spectroscopy for non-invasive diabetic detection based on a portable Raman spectrometer [J] . Zou Ye, Huang Meizhen, Wang Kehui, Laser physics letters . 2016,第6期

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2. Non-invasive quantitative assessment of the content of pharmaceutical capsules using transmission Raman spectroscopy. [J] . Eliasson C, Macleod NA, Jayes LC, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2008,第2期

机译：使用透射拉曼光谱法对药物胶囊含量进行无创定量评估。
3. Characterisation of transmission Raman spectroscopy for rapid quantitative analysis of intact multi-component pharmaceutical capsules. [J] . Hargreaves MD, Macleod NA, Smith MR, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2011,第3期

机译：透射拉曼光谱的表征，用于完整多组分药物胶囊的快速定量分析。
4. Characterisation of a Novel Transmission Raman Spectroscopy Platform for Non-Invasive Detection of Breast Micro-Calcifications [C] . Adrian Ghita, Pavel Matousek, Nick Stone Biomedical vibrational spectroscopy 2018: Advances in research and industry . 2018

机译：用于乳腺微钙化的非侵入性检测的新型透射拉曼光谱平台的表征
5. Wide field measurements using a spatial heterodyne Raman spectrometer for transmission raman spectroscopy and standoff detection. [D] . Fessler, Kimberly A. 2016

机译：使用空间外差拉曼光谱仪进行透射拉曼光谱和对峙检测的宽视野测量。
6. Characterising variances of milk powder and instrumentation for the development of a non-targeted Raman spectroscopy and chemometrics detection method for the evaluation of authenticity [O] . Sanjeewa R. Karunathilaka, Samantha Farris, Magdi M. Mossoba, -1

机译：表征奶粉的差异和用于开发非目标拉曼光谱和化学计量学检测方法的仪器以评估真伪
7. High sensitivity non-invasive detection of calcifications deep inside biological tissue using Transmission Raman Spectroscopy [O] . Ghita A, Matousek P, Stone N 2017

机译：透射拉曼光谱法对生物组织内部钙化的高灵敏度非侵入性检测
8. Detection and Quantitative Analysis of Chemical Species in Hanford Tank Materials211 Using Raman Spectroscopy Technology: FY94 Florida State University Raman 211 Spectroscopy Report [R] . Reich, F. R. 1997

机译：使用拉曼光谱技术检测和定量分析Hanford罐料211中的化学物质：FY94佛罗里达州立大学拉曼211光谱报告

Characterisation of a Novel Transmission Raman Spectroscopy Platform for Non-Invasive Detection of Breast Micro-Calcifications

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