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首页> 外文会议>IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine >Difference in Associations of Polymorphic Variants of the Serotonin Transporter Gene with Resting-state EEG in Younger and Older Adults
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Difference in Associations of Polymorphic Variants of the Serotonin Transporter Gene with Resting-state EEG in Younger and Older Adults

机译：血清素转运蛋白基因多晶型变体与休息状态脑电图患者患者患者的差异差异

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We have previously shown that oscillatory baseline brain activity, attention tasks, and indices of orienting reaction are associated with 5-HTTLPR and STin2VNTR polymorphisms of serotonin transporter gene in age specific way. To better understand the genetic base of aging-related differences in brain function and behavior, this study aimed to investigate the combined effects of 5-HTTLPR and STin2VNTR polymorphisms on the resting-state electroencephalographic spectral power in 8 functional frequency bands under eyes closed and eyes open conditions in younger (19-35 years old, N = 217) and older (over 55 years old, N = 107) age groups and whether these EEG effects mediate properties of attention. Based on two polymorphisms of serotonin transporter gene (5-HTTLPR and STin2VNTR), three genotypes combinations were generated to reflect different levels of gene expression (low intermediate, and high). Difference in the EEG power associated with levels serotonin transporter gene expression was found only in older subjects. Under eyes open condition, carries of combination with high expression had reduced alpha 2, 3 and beta 1 activity in comparison with other combinations mainly in the posterior brain regions. Results of mediation analysis revealed that resting-state EEG properties mediated the effects of 5-HTTLPR and Stin2VNTR genotypes combinations on orienting reaction, so that high expression genotype was associated with lower estimates of alpha and beta EEG power, which in turn were translated into more pronounced orienting reaction.
机译：我们之前已经表明，定向反应的振荡基线大脑活动，关注任务和定向反应的指标与血清素转运蛋白基因的5-httlpr和stin2vntr多态性相关联。为了更好地了解脑功能和行为的衰老相关差异的遗传基础，该研究旨在研究5-HTTLPR和STIN2VNTR多态性在闭合眼睛下的8个功能频带中静态脑电图谱功率的综合影响年轻人（19-35岁，N = 217）和较大（超过55岁，N = 107）年龄段，以及这些EEG效应是否调解关注的物质。基于血清素转运蛋白基因（5-HTTLPR和STIN2VNTR）的两种多态性，产生了三种基因型组合以反映不同水平的基因表达（中间体和高）。与水平血清素转运蛋白转运基因表达相关的EEG能量的差异仅在较旧的受试者中发现。在眼睛打开状态下，与主要在后脑区域的其他组合相比，与高表达的组合具有降低的α2,3和β1活性。调解分析结果显示，静息状态EEG性质介导5-HTTLPR和STIN2VNTR基因型对取向反应的影响，使高表达基因型与较低估计的α和β脑电图估计有关，又转化为更多明显的定向反应。

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