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首页> 外文会议>IEEE International Conference on Smart Information Systems and Technologies >Development of the Patient-Specific Ocular Models using Optical Coherence Tomography Images: Glaucoma Model
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Development of the Patient-Specific Ocular Models using Optical Coherence Tomography Images: Glaucoma Model

机译：使用光学相干断层扫描图像的患者特异性眼模型的发展：青光眼模型

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Glaucoma is the leading cause of blindness worldwide. It is an eye disease characterized by progressive loss of retinal ganglion cell (RGC) axons. Biomechanical factors are believed to play a central role in the RGC loss, whereas the specific mechanism remains unknown. Our goal is to propose a methodology to build patient specific ocular models to characterize the effect of intraocular (IOP) and intracranial pressure (ICP) on the optic nerve head (ONH). Optical coherence tomography (OCT) images of the eyes of six patients were obtained and three-dimensional models of the ONH region were reconstructed. These were further embedded into a generic cornea-scleral shell to create complete eye models. We used finite element analysis to determine the effects of elevated levels of IOP with varying levels of ICP on the ONH biomechanical environment. Maximum principal and shear strains were computed and used for assessing ONH damage. Our results reveal cases with substantial shear strains in lamina cribrosa and indicate that the inter-individual geometric variations affect ONH biomechanics.
机译：青光眼是全球失明的主要原因。它是一种眼部疾病，其特征在于视网膜神经节细胞（RGC）轴突的渐进性丧失。据信生物力学因素在RGC损失中发挥着核心作用，而具体机制仍然未知。我们的目标是提出一种构建患者特异性眼模型的方法，以表征眼内（IOP）和颅内压（ICP）对视神经头部（ONH）的影响。获得六名患者眼睛的光学相干断层扫描（OCT）图像，重建了onh区域的三维模型。这些进一步嵌入通用角膜巩膜壳中以创造完整的眼睛模型。我们使用有限元分析来确定IOP升高水平在ONH生物力学环境上不同水平的ICP的影响。计算最大主体和剪切菌株并用于评估损伤。我们的结果揭示了Lamina Cribrosa中具有大量剪切菌株的病例，并表明单个间几何变异影响了ONH生物力学。

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