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首页> 外文会议>International Congress on Nutrition and Metabolism in Renal Disease;ICRNM 2012 >Smaller Mean Corpuscular Volume May Predict Good Response to Oral Iron Administration for Anemia in Hemodialysis Patients with Low Levels of Hepcidin-25 and Ferritin
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Smaller Mean Corpuscular Volume May Predict Good Response to Oral Iron Administration for Anemia in Hemodialysis Patients with Low Levels of Hepcidin-25 and Ferritin

机译：较小的平均碎石体积可以预测血液透析患者血液透析患者血清素-25和铁蛋白水平低的口腔抗血症的良好反应

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Background Hepcidin-25 is a key peptide-hormone of iron metabolism and iron absorption of small intestine. The low hepcidin-25 state leads to an increase in intestinal iron absorption and iron efflux from tnacrophage. In hemodialysis (HD) patients, iron deficiency is one of the important factors of anemia. However, it remains elusive whether there is a difference in the response to oral iron administration between HD patients with low hepcidin-25 levels and smaller mean corpuscular volume (MCV) and those with normal MCV.Subjects and Methods Hepcidin-25 was measured in 66 patients on maintenance HD. Of the 66 cases, 14 cases with low serum levels of hepcidin-25 (<14ng/ml) were enrolled in the study. We examined the correlation between the based MCV and a gain in hemoglobin (Hb) after oral iron (sodium ferrous citrate) administration. Hb was measured before and 8 weeks after oral iron administration. Serurn levels of hepcidin-25 were measured using a high- throughput LC-MS/MS method. Serurn levels of ferritin, hepcidin-25, MCV and Hb were measured before starting HD at the beginning of the week when HD became vacant for 2 days.Results In 66 cases, mean serurn levels of hepcidin-25 were 14.0± 22.6ng/ml. Serum levels of hepcidin-25 were positively correlated with those of ferritin. The MCV was under 88fL in 6 cases (low MCV group, HD duration, 8.7±4.4 years, and oral iron dose, 50mg/day), and the other 8 cases snowed normal MCV (normal MCV group, HD duration, 7.3±4.6 years, and oral iron dose, 62.5mg/day). In low MCV group, Hb significantly increased, but remained unchanged in normal MCV group. A gain in Hb was significantly greater in low MCV group (3.1 ± 1.2g/dl, p<0.01) than that in normal MCV group (0.8±2.2g/dl). Hb, ferritin and hepcidin-25 levels did not differ between groups.Conclusions In a state of low serum levels of hepcidin-25 and fenitin, oral iron administration is more effective for anemia in patients with low MCV than in those with normal MCV.
机译：背景技术Hepcidin-25是铁代谢的关键肽激素和小肠的铁吸收。低肝素-25状态导致肠道铁吸收和来自TNAcrophage的铁流出的增加。在血液透析（HD）患者中，铁缺乏是贫血的重要因素之一。然而，它仍然难以实现对低肝素-25水平的高清患者的响应和较小的平均碎石体积（MCV）和具有正常MCV的人和方法的响应响应差异。在66中测量Hepcidin-25的患者维修高清患者。在66例中，研究了14例低血清血清水平的肝素-25（<14ng / ml）。我们在口服铁（柠檬酸钠）给药后，检查了基于MCV与血红蛋白（HB）的增益之间的相关性。 HB在口服铁施用后8周之前测量。使用高通量LC-MS / MS法测量肝素-25的升级水平。在一周开始时开始HD在HD在空置2天的时间开始之前测量升级水平。在66例中，Hepcidin-25的平均升级水平为14.0±22.6ng / ml 。血清肝素-25的水平与铁蛋白的血清水平呈正相关。 MCV在88次以下6例（低MCV组，高清持续时间，8.7±4.4岁和口服铁剂量，50mg /天），以及其他8例下雪普通MCV（正常MCV组，高清持续时间，7.3±4.6多年和口服熨斗剂量，62.5mg /天）。在低MCV组中，HB显着增加，但在正常的MCV组中保持不变。低MCV组（3.1±1.2g / dL，P <0.01）中Hb的增益明显大于正常MCV组（0.8±2.2g / dL）。 Hb，铁蛋白和肝素-25水平在群体的低血清素水平和芬林蛋白水平的状态下没有差异，口服铁给药对患者的贫血患者比具有正常MCV的患者更有效。

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