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首页> 外文会议>CBCME 2011;International Conference on Biotechnology, Chemical and Materials Engineering >Amphetamine-Induced Locomotion and Brain Stimulation Reward Research and Applications
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Amphetamine-Induced Locomotion and Brain Stimulation Reward Research and Applications

机译：amphetamine诱导的运动和脑刺激奖励研究和应用

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摘要

Amphetamine, a dopamine agonist, has an effect on increasing dopamine level in certain brain regions, like the nucleus accumben and the ventral tegmental area (Yoshida et al., 1992). Hence, it increases reward-related functions. In the current study, we examined the changes in the frequency of locomotion in previously habituated mice after 3mg/kg amphetamine injections. In the same way, we also monitored the changes in bar pressing rates of previously trained rates after 2mg/kg amphetamine injections. Though not showing a significant statistical result, both graphs and discussions supported that amphetamine injection increased horizontal quadrants crossings compared with saline injection. While the amphetamine administration increased bar press rate in previously trained rats at low frequencies, it led the rats to fewer bar presses at higher frequencies compared with both the baseline and the saline condition. The results of both experiments consistent with past studies which claim that amphetamine acts as a dopaminergic agonist and increases reinforcing capacity through enhancement of dopaminergic transmission (Gallistel & Karras, 1984).
机译：Amphetamine是一种多巴胺激动剂，对某些脑区中的多巴胺水平增加了多巴胺水平，如核宫颈和腹侧腺嘌呤区域（Yoshida等，1992）。因此，它增加了与奖励相关的功能。在目前的研究中，我们在3mg / kg amphetamine注射后检查了先前居住小鼠的运动频率的变化。以同样的方式，我们还监测2mg / kg kg amphetamine注射后先前训练的速率的条形按率的变化。虽然没有显示出显着的统计结果，但是与盐水注射相比，既有图表和讨论都支持安非他明注射增加的水平象限过关。虽然安非胺给药在先前培训的大鼠处于低频时增加了杆压力速率，但与基线和盐水条件相比，它以更高的频率导致大鼠更少的条压力机。兼顾与过去的研究一致的两种实验结果，其声明Amphetamine作为多巴胺能激动剂，通过增强多巴胺能传输（Gallistel＆Karras，1984）增加增强能力。

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