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Nonlinear Dynamics of Heart Rate Variability in Children with Asthmatic Symptoms

机译:哮喘症状儿童心率变异性的非线性动力学

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摘要

Asthma is a chronic lung disease that is prone to start during chilhood. Although symptoms can be usually controlled with medication, early diagnosis is crucial to reduce the risk of permanent airway obstruction. Despite the fact that origin of asthma is still uncertain, abnormal parasympathetic nervous system (PNS) activity has been pointed out to play a major role in its pathogenesis. In this work the use of nonlinear heart rate variability (HRV) indexes is proposed in order to look for differences between children classified as high-or low-risk of suffering from asthma in the future. PNS activity is assessed trough a filtered HRV signal. Correlation dimension analysis showed statistically significant differences distinguishing high-and low-risk. Decreased complexity observed in high-risk group suggests that abnormal PNS activity might be related with increased risk of developing asthma.
机译:哮喘是一种慢性肺病,易于在唇胀过程中开始。 虽然症状通常可以用药物控制,但早期诊断对于降低永久气道阻塞的风险至关重要。 尽管哮喘的起源仍然不确定,但已经指出了异常的副交感神经系统(PNS)活性在其发病机制中起主要作用。 在这项工作中,提出了使用非线性心率变异性(HRV)指标,以便在未来归类为患有哮喘患有哮喘的高或低风险的儿童之间的差异。 评估PNS活动的滤波过滤的HRV信号。 相关尺寸分析显示出具有高低风险的统计学意义差异。 在高风险组中观察到的复杂性降低表明,异常的PNS活性可能与发育哮喘的风险增加有关。

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