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Design and modeling of a prototype fiber scanning CARS endoscope

机译:原型光纤扫描CARS内窥镜的设计与建模

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摘要

An endoscope capable of Coherent Anti-Stokes Raman scattering (CARS) imaging would be of significant clinical value for improving early detection of endoluminal cancers. However, developing this technology is challenging for many reasons. First, nonlinear imaging techniques such as CARS are single point measurements thus requiring fast scanning in a small footprint if video rate is to be achieved. Moreover, the intrinsic nonlinearity of this modality imposes several technical constraints and limitations, mainly related to pulse and beam distortions that occur within the optical fiber and the focusing objective.rnHere, we describe the design and report modeling results of a new CARS endoscope. The miniature microscope objective design and its anticipated performance are presented, along with its compatibility with a new spiral scanning-fiber imaging technology developed at the University of Washington. This technology has ideal attributes for clinical use, with its small footprint, adjustable field-of-view and high spatial-resolution. This compact hybrid fiber-based endoscopic CARS imaging design is anticipated to have a wide clinical applicability.
机译:具有相干抗斯托克斯拉曼散射(CARS)成像功能的内窥镜对于改善腔内癌的早期检测具有重要的临床价值。但是,由于多种原因,开发该技术具有挑战性。首先,非线性成像技术(例如CARS)是单点测量,因此,如果要实现视频速率,则需要在较小的占用空间内进行快速扫描。此外,这种模式的固有非线性强加了一些技术约束和局限性,主要与光纤和聚焦物镜中发生的脉冲和光束畸变有关。在此,我们描述新型CARS内窥镜的设计并报告其建模结果。介绍了微型显微镜的物镜设计及其预期性能,以及与华盛顿大学开发的新型螺旋扫描纤维成像技术的兼容性。该技术具有占地面积小,可调节的视野和高空间分辨率等优点,是临床使用的理想属性。这种紧凑的基于混合纤维的内窥镜CARS成像设计有望具有广泛的临床应用性。

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