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首页> 外文会议>Conference on optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy >Exploitation of interstitial brachytherapy techniques for photodynamic therapy--I. Treatment planning for interstitial photoexcitation therapy: a photodosimetry treatment planning system
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Exploitation of interstitial brachytherapy techniques for photodynamic therapy--I. Treatment planning for interstitial photoexcitation therapy: a photodosimetry treatment planning system

机译：光动力治疗间质近距离放射治疗技术的开发 - I。间质透透诊疗的治疗计划：光电沸腾治疗计划系统

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A photodosimetry computer program, T-PIPET, was developed to rapidly compute maps of relative light intensity within tumors illuminated by implanted optical fibers. Light attenuation was measured along radial tracks from laterally-diffusing fibers implanted into both the R3327-AT and R3327-H Dunning rat prostate carcinomas and input to the computer program. The calculations assumed (1) uniform optical property of tissue through the tumor, (2) uniform and equal illuminance from the length of optical diffuser and between fibers and (3) precise needle implantation. Values of relative light intensity were computed, color-coded and imaged for a 5 $MUL 5 cm tumor cross section (a 150 $MUL 150 pixel array). Illuminators consisting of seven laterally-diffusing fibers implanted as six adjacent equilateral triangles were tested. The uniformity of light fields within encompassed tumor volumes was determined as a function of fiber spacing. Measures of light intensity along specific tracks within tumors agreed well ($POM 10%) with values of relative light intensity predicted by T-PIPET. The rapid falloff of light dose beyond the illuminator will assist in minimizing normal tissue damage outside the tumor volume. To cure slid tumors, a specific light dose must be delivered throughout the tumor volume and recurrence might be expected from tumor zones which are underdosed. A 9-fiber illuminator has been constructed to deliver light more uniformly to the tumor periphery. These illuminators have been tested with R3327-AT tumors illuminated with 673 nm light after i.v. administration of a pheophorbide-base photosensitizer.
机译：光电二滴定电脑程序T-PIPET开发成快速计算通过植入光纤照射的肿瘤内的相对光强度的图谱。沿横向轨道测量光衰减，从横向扩散纤维注入到R3327-AT和R3327-H令人垂涎的大鼠前列腺癌和输入到计算机程序中。计算（1）组织的均匀光学性能通过肿瘤，（2）从光学扩散器的长度和纤维之间的长度和（3）精确的针头植入均匀和等于照明。计算相对光强度的值，针对5 $ MUL 5 CM肿瘤截面（150 $ MUL 150像素阵列）进行颜色编码和成像。测试由植入六个相邻的等边三角形的七个横向扩散纤维组成的发光器。被包容肿瘤体积内的光场的均匀性作为纤维间距的函数确定。肿瘤内的特定轨道的光强度测量良好（$ POM 10％），具有通过T-POVET预测的相对光强度的值。光剂量超出照明器的快速衰脱将有助于最小化肿瘤体积外的正常组织损伤。为了固化滑动肿瘤，必须在整个肿瘤体积中递送特定的光剂量，并且可能预期肿瘤区域的复发。建造了9纤维照明器以更均匀地递送到肿瘤周边的光。这些照明器已经用R3327进行测试 - 在I.v后用673nm光照射的肿瘤。施用伯酚基碱光敏剂。

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