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A Computational Model of Gene Regulatory Networks and its Topological Properties

机译:基因调控网络的计算模型及其拓扑性质

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摘要

A new model for Gene Regulatory Networks (GRN) is proposed. The model is potentially more biologically sound than other approaches, and is based on the idea of an artificial genome from which several products like genes, mRNA, miRNA, non-coding RNA, and proteins are extracted. These products are connected giving rise to a heterogeneous directed graph. The topology of the obtained networks is studied using degree distributions. We make some considerations about the biological meaning of the outcomes of these simulations.
机译:提出了一种新的基因调控网络模型。该模型可能比其他方法在生物学上更合理,并且基于人工基因组的思想,该基因组可从中提取几种产物,如基因,mRNA,miRNA,非编码RNA和蛋白质。这些产品连接起来会产生异构的有向图。使用度分布研究获得的网络的拓扑。我们对这些模拟结果的生物学意义进行了一些考虑。

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  • 来源
    《》|2008年|P.204-211|共8页
  • 会议地点 Winchester(GB)
  • 作者单位

    Centre of Informatics and Systems of the University of Coimbra European Space Agency Rome;

    Department of Informatics Engineering University of Coimbra Centre of Informatics and Systems of the University of Coimbra;

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