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首页> 外文会议>Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Inter-Session Repeatability of Retinal Layer Thickness in Optical Coherence Tomography
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Inter-Session Repeatability of Retinal Layer Thickness in Optical Coherence Tomography

机译：光学相干断层扫描中视网膜厚度的间间可重复性

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Reliable retinal layer thickness measurements using optical coherence tomography (OCT) are important to track the subtle retinal changes in longitudinal studies. A total of 10 eyes (5 healthy subjects, 40±13 years old) were enrolled to study the inter-session repeatability and identify the pitfalls affecting the reliabilities. Each eye was scanned using spectral domain OCT (Spectralis SDOCT, Heidelberg Engineering) for 3 sessions with 30 seconds rest in between. The first and second sessions were scanned independently and the third one was scanned with the first one as the baseline visit. Each session consisted of a confocal scanning laser ophthalmoscopy (cSLO) image and 61 B-scans of 496×768 pixels. The first, second and third sessions were named as baseline, unregistered and registered sessions; respectively. Seven retinal layers labeled as RNFL, GCL+IPL, INL, OPL, ONL, IS and OS were segmented using a custom software (OCTRIMA3D) and measured in the ETDRS grid. Inter-session standard deviation (σ), coefficient of repeatability (CR) and coefficient of variations (COV) were calculated to quantify the repeatability. Paired t-test of COVs was used to compare the repeatability and the level of significance was set at 5%. We obtained that values of the CR >5 μm and COV of 5%, were revealed only in the outer layers. The values of COV were not significantly different (p<0.05) in the unregistered scanning session. Our results show that the rotations in the unregistered scanning sessions do not cause significant change in repeatability.
机译：使用光学相干断层扫描（OCT）可靠的视网膜厚度测量值对于追踪纵向研究的微妙视网膜变化非常重要。共有10只眼睛（5个健康的科目，40±13岁）读取会话间重复性，并确定影响可靠性的陷阱。使用频谱域OCT（Spectralis SDOCT，海德堡工程）扫描每只眼睛3个休息30秒的3个课程。第一届和第二次会话是独立扫描的，第三个是第一个作为基准访问的第三个会议。每个会议由共聚焦扫描激光眼镜（CSLO）图像和496×768像素的61b扫描组成。第一个，第二和第三届会议被命名为基线，未注册和注册会话;分别。使用自定义软件（Octrima3D）分段为RNFL，GCL + IPL，INL，OPL，ONL，OPL，OPL，ONL，OPL，ONL的七层，并在ETDRS网格中测量。计算间间标准偏差（σ），计算重复性（CR）和变型系数（COV）以量化可重复性。 COV的配对T检验用于比较可重复性，并且意义程度设定为5％。我们获得了Cr>5μm和CoV的值，仅在外层中透露。在未注册的扫描会话中，COV的值没有显着差异（P <0.05）。我们的结果表明，未注册扫描会话中的旋转不会导致重复性的显着变化。

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