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首页> 外文会议>Conference on Biomedical Applications in Molecular, Structural, and Functional Imaging >Decreased Triple Network Connectivity in Patients with Post-traumatic Stress Disorder
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Decreased Triple Network Connectivity in Patients with Post-traumatic Stress Disorder

机译：创伤后应激障碍患者的三维网络连通性降低

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摘要

The triple network model provides a common framework for understanding affective and neurocognitive dysfunctions across multiple disorders, including central executive network (CEN), default mode network (DMN), and salience network (SN). Considering the effect of traumatic experience on post-traumatic stress disorder (PTSD), this study aims to explore the alteration of triple network connectivity in a specific PTSD induced by a single prolonged trauma exposure. With arterial spin labeling sequence, three networks were identified using independent component analysis in 10 PTSD patients and 10 healthy survivors, who experienced the same coal mining flood disaster. In PTSD patients, decreased connectivity was identified in left middle frontal gyrus of CEN, left precuneus and bilateral superior frontal gyrus of DMN, and right anterior insula of SN. The decreased connectivity in left middle frontal gyrus was identified to associate with clinical severity. These results indicated the decreased triple network connectivity, which not only supported the proposal of the triple network model, but also prompted possible neurobiology mechanism of cognitive dysfunction for this kind of PTSD.
机译：三网模型提供了一个常见的框架，用于了解多种障碍，包括中央行政网络（CEN），默认模式网络（DMN）和Parience Network（SN）的常见框架。考虑到创伤经验对创伤后应激障碍（PTSD）的影响，本研究旨在探讨由单个延长的创伤暴露诱导的特定PTSD中三网连通性的改变。通过动脉旋转标记序列，使用10名PTSD患者和10名健康幸存者的独立组分分析鉴定了三个网络，经历了相同的煤炭洪水灾难。在PTSD患者中，CEN的左侧前额相回合中鉴定了降低的连接，留下了DMN的双侧前额相和SN的右前肠道。鉴定左侧正面回收中的连续性降低以与临床严重程度相关联。这些结果表明了三维网络连接下降，这不仅支持三网模型的提议，而且促进了这种PTSD认知功能障碍的可能神经生物学机制。

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