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首页> 外文会议>IEEE Nuclear Science Symposium;Medical Imaging Conference >PET-18F-FDG Pharmacokinetic Modeling without Blood Sampling in Arteries with Atherosclerosis
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PET-18F-FDG Pharmacokinetic Modeling without Blood Sampling in Arteries with Atherosclerosis

机译：PET-18F-FDG药代动力学建模，没有动脉粥样硬化的动脉中抽血

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Pharmacokinetic modeling of 18F-FDG in the arteries is necessary in comparison to the standard uptake value (SUV) and tissue-to-blood ratio (TBR) for two main reasons: the small thickness of the artery wall (around 2.3 mm) and the domination by activity emanating from blood. Consequently, the artery image is subject to partial volume effect (PVE) and it is not appropriate to use an input function IF determined from an artery. In the present work, we used a modified pharmacokinetic model derived from the classical two-tissue compartment model of 18F-FDG. In the classical model, the artery time-activity curve (TAC) is fitted with the model convolved with the IF to calculate the rate constants together with tissue blood volume (TBV) which is a fraction of IF $(pmb{TBV}=pmb{k_{5}}pmb{IF}, pmb{k_{5}} < pmb{1})$. In the modified model, the images are decomposed with factor analysis (FA) to provide blood image. The same region of interest of the artery is used in the blood image to determine TBV. The model is therefore rewritten to convolve the model with TBV/k5. Such model, called without blood sampling (WOBS) has several advantages mainly, since the same region of interest (ROI) is used for both TBV and the artery, PVE cancels out. We applied these two models and SUV to artery images in patients with atherosclerosis, with and without medication. For the classical model, artery TAC and IF, determined on the sagittal view of the aorta, were corrected for PVE. The metabolic rate of glucose (MRG) was calculated in 710 artery image slice with both models. We also compared MRG as a function of the ratio of CT calcification area (RCA) and Agatston calcification scores (ACS). TAC fits with WOBS were more accurate in almost all artery TACs and MRG had globally less variation with WOBS. MRG values in non-medication group were statistically significantly different in both models. WOBS and the classical model also detected the same differences between RCA and ACS.
机译：与标准摄取值（SUV）和组织与血液比（TBR）相比，动脉中18F-FDG的药代动力学建模是必要的两个主要原因：动脉壁的厚度小（约2.3毫米）和血液发出的活动统治。因此，动脉图像受部分体积效应（PVE），如果从动脉确定，则不合适使用输入功能。在本作工作中，我们使用了衍生自18F-FDG的经典双组织隔室模型的改良药代动力学模型。在经典模型中，动脉时间 - 活动曲线（TAC）配有卷曲的模型，该模型与组织血容量（TBV）一起计算速率常数，这是一部分 $（ pmb {tbv} = pmb {k_ {5}} pmb {if}， pmb {k_ {5}} < pmb {1}）$ 。在修改模型中，图像用因子分析（FA）分解以提供血液图像。动脉的相同兴趣区域用于血液图像以确定TBV。因此，该模型重写为使用TBV / k卷曲模型 5 。这种模型，不含血液采样（WOB）的优点主要是主要的优点，因为相同的感兴趣区域（ROI）用于TBV和动脉，PVE抵消。我们将这两种模型和SUV应用于动脉粥样硬化，随后的动脉粥样硬化患者的动脉图像。对于典型的模型，动脉TAC和IF，如果在主动脉的矢状视图上纠正PVE。葡萄糖（MRG）的代谢率在710个动脉图像切片中计算出两种模型。我们还将MRG与CT钙化区域（RCA）和Agatston钙化分数（ACS）的比率进行比较。在几乎所有动脉TAC和MRG几乎所有动脉TAC都更加准确，MRG与湿润的全部变化。两种模型中非药物组中的MRG值在统计学上显着不同。 WOB和古典模型也检测到RCA和ACS之间的差异相同。

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