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首页> 外文会议>Conference on reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications >Phosphorescent Nanoparticles and Their Applications for Time-Resolved Luminescent Biological Assays
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Phosphorescent Nanoparticles and Their Applications for Time-Resolved Luminescent Biological Assays

机译：磷光纳米粒子及其用于时间分辨发光生物测定的应用

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A new class of phosphorescent nanoparticles has been developed that use halogen-containing polymers and copolymers to encapsulate phosphorescent molecules. Their strong phosphorescence of long lifetime and large Stoke shift are not subject to oxygen quenching under ambient conditions due to the low oxygen permeability of the encapsulation matrix. The cross-linked phosphorescent particles are very stable and easily re-suspendable in aqueous media with surface functional groups to allow covalent tagging of biological recognition molecules such as antibodies. The conjugates can be used to provide very sensitive detection of analytes through time-resolved phosphorescence measurements. In addition to their applications for solution-based biological assays, those particles have also been demonstrated to be very useful for drychemistry- based time-resolved luminescent lateral flow assays
机译：已经开发了一种新的磷光纳米粒子，其使用含卤素的聚合物和共聚物来包封磷光分子。由于包封基质的低氧气渗透性，它们长寿命和大型叉蛎偏移的强磷光磷的强磷光消耗不受氧气猝灭的影响。交联的磷光粒子非常稳定并且容易在具有表面官能团的水性介质中再悬浮在水性介质中，以允许共价标记生物识别分子如抗体。缀合物可用于通过时间分辨的磷光测量来提供对分析物的非常敏感的检测。除了它们对基于溶液的生物测定的应用之外，还证明了这些颗粒对于基于干燥的时间分辨发光横向流动测定非常有用

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