Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging

机译：MMP-2和MMP-9光学成像淬火荧光三螺旋肽的表征

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

The prevalence of the gelatinases, MMP-2 and MMP-9, in many human tumors, including breast, colorectal, prostate and gastric cancer, make them an attractive target for molecular imaging. A self assembling homotrimeric triple helical peptide (THP), incorporating sequences from type V collagen with high specificity to MMP-2 and MMP-9, was previously developed. To investigate the viability of a THP for gelatinase imaging, we conjugated 5FAM to c-amino groups of lysine flanking the hydrolysis site and subjected this substrate (THP-5FAM) to vitro analysis. The synthesis and in vitro results was presented.

机译：在许多人类肿瘤中，包括乳腺癌，结直肠，前列腺和胃癌，包括乳腺癌，包括乳腺癌，结肠直肠癌，前列腺和胃癌的患病率，使其成为分子成像的有吸引力的靶标。先前，先前发育了一种自组装同型三螺旋肽（THP），将来自V型胶原蛋白的蛋白曲折的序列掺入MMP-2和MMP-9。为了研究THP对明胶酶成像的可行性，我们将5FAM缀合至赖氨酸的C-氨基，侧翼水解位点并进行该基材（THP-5FAM）至体外分析。介绍了合成和体外结果。

著录项

来源
《Conference on reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications》|2009年||共8页
会议地点
作者
Philip P. Cheney; Gregg B. Fields; Samuel Achilefu; W. Barry Edwards;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类医用物理学;
关键词
MMP; gelatinase; optical imaging; cancer; fluorescence;

机译：MMP;明胶酶;光学成像;癌症;荧光;

相似文献

外文文献
中文文献
专利

1. Evaluation of a Triple-Helical Peptide with Quenched Fluorophores for Optical Imaging of MMP-2 and MMP-9 Proteolytic Activity [J] . Xuan Zhang, Jamee Bresee, Philip P. Cheney Molecules . 2014,第6期

机译：淬灭荧光团的三螺旋肽的光学成像的MMP-2和MMP-9蛋白水解活性的评估。
2. Evaluation of a Triple-Helical Peptide with Quenched Fluorophores for Optical Imaging of MMP-2 and MMP-9 Proteolytic Activity [J] . Baogang Xu, Gregg B. Fields, Jamee Bresee, Molecules . 2014,第6期

机译：淬灭荧光团的三螺旋肽的光学成像的MMP-2和MMP-9蛋白水解活性的评估。
3. Near-infrared triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity in vivo [J] . ZhangX., BreseeJ., FieldsG.B., Bioorganic and Medicinal Chemistry Letters . 2014,第16期

机译：具有淬灭荧光团的近红外三螺旋肽，用于体内MMP-2和MMP-9蛋白水解活性的光学成像
4. Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging [C] . Philip P. Cheney, Gregg B. Fields, Samuel Achilefu, Reporters, markers, dyes, nanoparticles, and molecular probes for biomedical applications . 2009

机译：用于MMP-2和MMP-9光学成像的淬灭荧光三螺旋肽的表征
5. Application and development of NMR spectroscopy to study the conformation and dynamics of collagen-like triple helical peptides. [D] . Li, Yingjie. 2007

机译：NMR光谱学在研究类胶原三螺旋肽的构象和动力学方面的应用和发展。
6. Evaluation of a Triple-Helical Peptide with Quenched Fluorophores for Optical Imaging of MMP-2 and MMP-9 Proteolytic Activity [O] . Xuan Zhang, Jamee Bresee, Philip P. Cheney, 2014

机译：淬灭荧光团的三螺旋肽的光学成像的MMP-2和MMP-9蛋白水解活性的评估。
7. Evaluation of a triple-helical peptide with quenched fluorophores for optical imaging of MMP-2 and MMP-9 proteolytic activity [O] . Zhang X, Bresee J, Cheney PP, 2014

机译：用淬灭荧光团评估三螺旋肽对MMP-2和MMP-9蛋白水解活性的光学成像

Characterization of quenched fluorescent triple helical peptides for MMP-2 and MMP-9 optical imaging

摘要

著录项

相似文献

相关主题

期刊订阅