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首页> 外文会议>SPIE Medical Imaging Conference >Is hippocampus getting bumpier with age: a quantitative analysis of fine-scale dentational feature under the hippocampus on 552 healthy subjects
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Is hippocampus getting bumpier with age: a quantitative analysis of fine-scale dentational feature under the hippocampus on 552 healthy subjects

机译：Hippocampus随着年龄的增长而获得掩盖：552个健康受试者在海马下的细尺牙本特征进行定量分析

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Shown in high resolution images, a morphological feature that can be clearly observed is the bumpy ridges on theinferior aspect of hippocampus, which we refer to as hippocampal dentation. The dentations of the hippocampus innormal individuals vary greatly from highly smooth to highly dentated. The degree of dentation could be an interestingfeature which has been shown to be correlated with episodic memory performance and not to be correlated withhippocampal volume. Here we presented a study which quantitatively evaluated the degree of bumpiness under thehippocampi in 552 healthy subjects with the age of mid-20 to 80. Specifically, the principal component analysis (PCA)which is nonlinearly fitted for quantifying the magnitude and the frequency of the hippocampal dentations has been usedto identify the major axes of the hippocampus and the dentations under it. Preliminary results have demonstrated that thelevel of dentations varies between left and right hippocampi in subjects, as well as across different age groups. This canestablish an objective and quantitative measurement for such a feature and can be extended for future comparisonsbetween non-clinical and clinical groups.
机译：在高分辨率图像中显示，可以清楚地观察到的形态特征是颠簸的山脊海马的劣质方面，我们称之为海马牙齿。海马的凹陷正常的人从高度光滑到高度牙齿变化很大。凹陷程度可能是一个有趣的已经显示出与情节内存性能相关的特征，而不与之相关海马体积。在这里，我们提出了一项研究，该研究是定量评估了陷阱下的程度海马在552名健康受试者中，20至80岁。具体而言，主要成分分析（PCA）这是非线性地安装用于量化的大小，并且已经使用了海马凹陷的频率识别海马的主要轴和它下面的牙齿。初步结果表明了牙齿水平在受试者中的左右海马之间变化，以及跨越不同年龄组。这个可以为这种特征建立客观和定量测量，并且可以扩展以延长未来的比较在非临床和临床组之间。

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