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首页> 外文会议>SPIE Medical Imaging Conference >Quantitative cartilage imaging using spectral photon-counting detector based computed tomography
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Quantitative cartilage imaging using spectral photon-counting detector based computed tomography

机译：使用光谱光子计数探测器基于计算断层扫描的定量软骨成像

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Glycosaminoglycans (GAG) in the extracellular matrix of the articular cartilage are biomarkers of cartilage health. Lossof GAG has been associated with early stage osteoarthritis, with zonal depletion of intra-articular GAG levels occurringprior to cartilage degeneration. Detecting this biochemical change in articular cartilage may facilitate early diagnosis ofosteoarthritis. GAG is negatively-charged and repels anionic contrast media. Increased uptake of anionic contrast agentscould be correlated with depleted GAG levels in the cartilage. Photon-counting detector (PCD) based computedtomography (CT) offers high-resolution imaging and x-ray energy discrimination capabilities. This allows delineation offiner anatomical structures, and the generation of quantitative material maps using energy-resolved CT data. In thisstudy, we demonstrate quantitative GAG imaging in porcine cartilage using a research whole-body PCD-CT system andan anionic contrast agent. Hind knee joints were harvested from euthanized pigs. GAG depletion mimicking early-OAwas induced using trypsin treatment. Both the control group and the trypsin-treated group were incubated in an anionicgadolinium contrast prior to PCD-CT scanning. The specimens were scanned at ultra-high resolution using the PCD-CTsystem at 120kV, 330mAs, and [25, 51] keV energy thresholds. An image-domain material decomposition wasemployed to generate the mass density map for gadolinium in cartilage using energy-resolved PCD-CT data. The resultsshowed significantly higher gadolinium uptake (p < 0.0001) in the trypsin-treated specimens, compared to the controlspecimens. We demonstrated high-resolution ex vivo cartilage imaging using PCD-CT to quantify gadolinium uptake inarticular cartilage as an inverse marker of GAG.
机译：关节软骨细胞外基质中的糖酰胺（GAG）是软骨健康的生物标志物。损失GAG与早期骨关节炎有关，具有关节内堵塞水平的区域枯竭在软骨退化之前。检测关节软骨的这种生化变化可以促进早期诊断骨关节炎。 GAG是负面的，并排斥阴离子造影媒体。增加阴离子造影剂的摄取可以与软骨中的耗尽Gag水平相关。基于光子计数检测器（PCD）计算断层扫描（CT）提供高分辨率成像和X射线能量辨别能力。这允许描绘使用能量分辨的CT数据更精细的解剖结构，以及数量材料图的产生。在这方面研究，我们展示了使用研究全身PCD-CT系统的猪软骨中的定量堵嘴成像阴离子造影剂。从安乐死的猪收获后膝关节。 Gag消耗模仿早期使用胰蛋白酶治疗诱导。对照组和胰蛋白酶处理的组都在阴离子中孵育PCD-CT扫描之前的钆对比度。使用PCD-CT以超高分辨率扫描标本系统在120kV，330mas和[25,51] Kev能量阈值。图像域材料分解是使用使用能量分辨的PCD-CT数据产生软骨中钆的质量密度图。结果与对照相比，在胰蛋白酶处理的标本中显示出显着更高的钆摄取（P <0.0001）标本。我们展示了使用PCD-CT的高分辨率eMVivo软骨成像来量化钆摄取关节软骨作为堵嘴的逆标记。

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