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首页> 外文会议>Conference on single-use technologies III >POLYMER INTERFACES AND BIOPHARMACEUTICALS: CHEMISTRY, DESIGNS AND CHALLENGES
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POLYMER INTERFACES AND BIOPHARMACEUTICALS: CHEMISTRY, DESIGNS AND CHALLENGES

机译：聚合物界面和生物药物：化学，设计和挑战

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The complex interactions between biological components and polymer materials has an extensive technical history. Virtually every surface property has been invoked as being important to biological interfacial response: texture, roughness, topology, porosity, hydrophilic, hydrophobic, polar, apolar, (non)-wettable, non-fouling brushes, surface mobility, rigidity, flexibility, crystalline versus amorphous, aspect ratio. Few surface properties alone, however, provide consistent, global technical solutions to vexing biomedical technology problems, particularly with cell culture, blood, plasma, microbial milieu, and protein solutions. Bio-interface materials performance must therefore be tailored specifically to each application. Short-term contact use (minutes/hours) has different materials interface requirements than long-term (days) use; globular proteins have particularly difficult needs not readily satisfied by any materials solution. Viable biologics interfaces (i.e., fresh blood harvests, cell cultures) must also consider selective gas permeability, leachables, and sterilization issues. Film properties, lamination, cutting, chemical stability, sealing and handling issues are additional considerations for single-use materials. Lastly cost-of-goods and materials economics must be considered, especially for single use technologies. No one-size-fits-all surface solutions currently satisfy all bio-interface materials needs. This talk will review design principles, dogma and actual polymer chemistries to modulate, modify and manipulate polymer surfaces in contact with biological components. Several polymer surface properties will be discussed with regard to their physical chemistry in aqueous media. Traditional and recent developments in non-fouling interfaces and polymer approaches and their hypothesized influences on biophysical interactions with proteins and cells will be presented.
机译：生物成分和聚合物材料之间的复杂相互作用具有广泛的技术历史。几乎每个表面属性都被调用为生物界面反应的重要性：质地，粗糙度，拓扑，孔隙，亲水，疏水，极性，非容性，（非） - 捻线，非污垢刷，表面迁移率，刚性，柔韧性，结晶与非晶，宽高比。然而，单独的表面性质少量提供衡新生物医学技术问题的一致，全球技术解决方案，特别是细胞培养，血液，血浆，微生物环境和蛋白质溶液。因此，必须专门针对每个应用程序量身定制生物界面材料性能。短期接触使用（分钟/小时）具有不同的材料界面要求，而不是长期（天）使用;球状蛋白质具有特别困难的需要不容易满足任何材料溶液。可行的生物学界面（即，新鲜血液收获，细胞培养物）还必须考虑选择性透气性，鹿浸润和灭菌问题。薄膜性质，层压，切割，化学稳定性，密封和处理问题是一次性材料的额外考虑因素。最后，必须考虑最终的商品和材料经济学，特别是对于单一使用技术。没有一种尺寸适合的所有表面解决方案目前满足所有生物界面材料的需求。该谈判将审查设计原则，教条和实际聚合物化学品以调节，修饰和操纵与生物组分接触的聚合物表面。将关于水性介质的物理化学讨论几种聚合物表面性质。将介绍非污染界面和聚合物方法的传统和最新的发展及其对与蛋白质和细胞的生物物理相互作用的假设影响。

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