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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Joint and Individual Neurotoxic Effects of Early Life Exposures to a Chemical Mixture: A Multi-Pollutant Approach Combining Ensemble Learning and G-Computation
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Joint and Individual Neurotoxic Effects of Early Life Exposures to a Chemical Mixture: A Multi-Pollutant Approach Combining Ensemble Learning and G-Computation

机译：早期寿命接触的关节和个体神经毒性对化学混合物的影响：一种多污染物方法组合集合学习和G-Computation

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Background: The majority of studies do not simultaneously consider multiple co-occuring exposures when assessing potential neurotoxicity. Objectives: To assess associations between developmental exposure to a mixture of pollutants and children's neurodevelopment using a novel approach. Methods: Concentrations of mercury (Hg), polychlorinated biphenyls (PCBs), and perfluoroalkyl substances (PFASs) were measured in maternal and children's blood at 5 years (n=449). At 7 years, children were administered Boston Naming Test (BNT) and the Strengths and Difficulties Questionnaire (SDQ). We used the G-formula combined with the SuperLearner -an ensemble learning technique- to infer effect estimates for the mixture of chemicals and for each pollutant while mutually adjusting for all exposures and potential confounders. We also constructed exposure-response curves and assessed potential interactions. Results: Most chemicals showed a negative relationship with BNT scores. An inter quartile range (IQR) increase in prenatal Hg and perfluorooctanoic acid (PFOA) concentrations was associated with 0.2 standard deviation [SD] (95% Confidence Interval [CI]: -0.3, 0) and 0.1 (95% CI: -0.3, -0.1) lower scores in the BNT, whereas a joint IQR increase in the mixture of chemicals was associated with 0.5 SD (95% CI: -0.7, -0.3) lower scores in the BNT. Additionally, an IQR increase in prenatal perfluoroctane sulfonic acid (PFOS) and PFOA concentrations was associated with 0.15 (95% CI: 0.1, 0.2) and 0.1 SD (95% CI: 0, 0.3) higher (worse) total SDQ scores. A joint IQR increase in chemicals mixture was associated with 0.2 SD (95% CI: -0.1, 0.4) higher SDQ scores. Finally, a joint IQR increase in 5-years mixture of chemicals was associated with 0.2 SD (95% CI: 0, 0.4) higher total SDQ scores. Conclusions: Using a novel multi-pollutant approach, we confirmed previously reported associations between mercury and lower cognitive function. Additional attention should be directed towards emerging PFASs.
机译：背景：大多数研究在评估潜在的神经毒性时，同时不能同时考虑多次共同发生暴露。目标：利用新方法评估发育暴露于污染物和儿童神经发育的混合物之间的关联。方法：在5年（n = 449），在母体和儿童血液中测量汞（Hg），聚氯氯联苯（PCB）和全氟烷基物质（PFASS）的浓度（n = 449）。 7年来，儿童被举行波士顿命名试验（BNT）和强度和困难问卷（SDQ）。我们使用G-Fapers与Superlearner-an集合学习技术相结合 - 以推断化学品和每种污染物混合的估计，同时相互调整所有暴露和潜在的混血。我们还构建了曝光响应曲线并评估了潜在的相互作用。结果：大多数化学品与BNT分数显示出负面关系。产前的幼株和全氟辛酸（PFOA）浓度的间歇范围（IQR）增加与0.2标准偏差相关[SD]（95％置信区间[CI]：-0.3,0）和0.1（95％CI：-0.3 ，-0.1）BNT中的得分降低，而化学品混合物的联合IQR增加与BNT中的0.5 sd（95％Ci：-0.7，-0.3）相关。另外，产前全氟乙烷磺酸（PFOS）和PFOA浓度的IQR增加与0.15（95％CI：0.1,0.2）和0.1SD（95％CI：0，0.3）较高（更差）总SDQ分数。化学品混合物的联合IQR增加与0.2SD（95％CI：-O1,0.4）的SDQ分数相关。最后，5年5年化学品混合物的联合IQR增加与0.2SD（95％CI：0，0.4）较高的总SDQ分数。结论：采用新型多污染物方法，我们确认先前报告了汞和较低的认知功能之间的关联。额外的注意力应针对新兴PFASS。

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