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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Using a passive sampler to measure the dermal migration of di(2-ethylhexyl)phthalate from polyvinylchloride flooring at different skin condition
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Using a passive sampler to measure the dermal migration of di(2-ethylhexyl)phthalate from polyvinylchloride flooring at different skin condition

机译：使用无源采样器测量不同皮肤条件下聚氯化氯化物地板的二（2-乙基己基）邻苯二甲酸酯的皮肤迁移

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Di(2-ethylhexyl)phthalate (DEHP) is still widely used as plasticizer in polyvinylchloride (PVC) products, although it is known to be toxic to human. One of the exposure pathways of DEHP from PVC products is the dermal migration. Generally, the dermal migration is measured from the transferred mass of a chemical per contact area and time. The dermal migration can occur through direct contact between human skin and PVC products or deposition of gaseous DEHP to human skin. In the case of the direct contact between skin and PVC products, the presence of sebum should be considered because sebum has high affinity to DEHP and might affect to the dermal migration rate. In this study, the dermal migration of DEHP from a PVC coated heating pad in direct contact condition with and without artificial sebum between a polydimethylsiloxane (PDMS) passive sampler and the heating pad were measured. The pre-cleaned PDMS sampler was attached on the heating pad or over filled artificial sebum in the gap between the sampler and the heating pad using custom made glassware. Those samples were stored at constant temperature 60 °C to simulated heating condition, taken after pre-designated sampling time, and DEHP was extracted using n-hexane and was analyzed with GC-MS. The dermal migration rates of DEHP from PVC with and without artificial sebum were 0.0378 and 0.00122 ug cmA-2 minA-l respectively, showing that artificial sebum accelerates the process by a factor of 30. Artificial sebum might be absorbed into PVC and PDMS, mimicking the real skin condition better than dry skin condition, without artificial sebum. Considering the covering matrices such as sebum is needed when assessing the exposure to DEHP through direct contact.
机译：二（2-乙基己基）邻苯二甲酸酯（DEHP）仍然广泛用作聚氯乙烯（PVC）的产品增塑剂，尽管已知是有毒的人类。一位来自PVC产品DEHP的暴露途径是皮肤移植。一般来说，皮肤的迁移是从每接触面积和时间的化学物质的转移质量测量。真皮迁移可通过人的皮肤和PVC制品或气态DEHP对人体皮肤的沉积之间的直接接触而发生。在皮肤和PVC产品之间的直接接触的情况下，皮脂的存在，应考虑，因为皮脂有DEHP高亲和力，可能会影响到皮肤的迁移率。在这项研究中，DEHP的从在具有和不具有聚二甲基硅氧烷（PDMS）被动采样和加热垫之间人工皮脂直接接触状态的PVC涂覆的加热垫真皮迁移测定。取样器安装在加热垫或通过在采样和使用自定义加热垫之间的间隙填充人工皮脂的预清洁PDMS制成玻璃器皿。这些样品保存在恒温60℃至模拟加热条件，预先指定的采样时间后取出，并用正 - 己烷萃取DEHP，并用GC-MS进行分析。从PVC DEHP的真皮迁移速率有和没有人工皮脂分别为0.0378和0.00122微克CMA-2米娜-1，示出了人工皮脂由30人工皮脂的因数加速过程可能被吸收到PVC和PDMS，模仿真正的皮肤状况比干燥的皮肤状况较好，无需人工皮脂。考虑到覆盖物如评估通过直接接触的接触DEHP当需要皮脂矩阵这样。

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