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首页> 外文会议>Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology >Contributions of exposure-related behaviors and dietary factors to organophosphate pesticide exposure in Japanese toddlers
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Contributions of exposure-related behaviors and dietary factors to organophosphate pesticide exposure in Japanese toddlers

机译：曝光相关行为和日本幼儿有机磷农药暴露的膳食因素的贡献

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Several epidemiological studies suggested that exposure to organophosphate (OP) pesticides could elicit adverse health effects on children. The objectives in this study were to reveal the OP exposure levels in Japanese toddlers and to explore the possible contributions of their exposure-related behaviors and their mothers' considerations of food selection and preparation to the exposure levels, considering one-day intake of foodstuffs. We recruited children participating in Japan Environment and Children's Study at Aichi regional center, and collected used disposable diapers from 1037 children (16-23 months old, 531 boys and 506 girls) from June 2015 to August 2016. Six urinary dialkylphosphates (DAPs) were measured using urine extracted from diapers by ultra-performance liquid chromatography with tandem mass spectrometry. The information about exposure-related behaviors, considerations of food selection and preparation, and foodstuffs were obtained from questionnaires. The geometric mean of ZDAP (total DAPs) concentrations and amounts excreted onto diaper during a night were 120 nmol/L and 13.4 nmol. In binary logistic regression analyses, use of an insecticide, an herbicide, an insect repellent spray, and a fragrance or a deodorant increased odds ratios (ORs) of the exposure levels (top 5% of urinary DAP concentrations or amounts) (ORs: 2.1-2.6). Receiver-operating characteristics curve analysis revealed that discriminatory power to determine whether or not ZDAP concentrations and the amounts exceeded their 95th percentile values was lower for the respective propensity scores for the exposure-related behaviors (area under the curve 0.72 and 0.74) and the considerations of food selection and preparation (0.60 and 0.67) than that for the foodstuffs taken on the survey day (0.89 and 0.91). We revealed the exposure levels of OP pesticides in Japanese toddlers. The contributions of the exposure-related behaviors and the considerations of food selection and preparation to the exposure levels were likely much smaller than that of foodstuffs.
机译：几项流行病学研究表明，暴露于有机磷（OP）杀虫剂可能引起对儿童的不利健康影响。本研究的目标是揭示日本幼儿的OP暴露水平，并探讨其曝光相关行为的可能贡献及其母亲对食物选择的母亲选择和准备水平的考虑因素，考虑到一天的食品。我们招募了参与日本环境和儿童学习的儿童在Aichi区域中心，并从2015年6月至2016年8月到8月的1037名儿童（16-23个月，531个月，531个男孩和506名女孩）收集了使用的一次性尿布。六次尿磷酸二磷酸盐（DAP）是通过用串联质谱法通过超级性液相色谱法从尿布中提取的尿液测量。关于曝光相关行为，食物选择和准备的考虑以及食品的信息是从问卷中获得的。 Zdap（总滴定）浓度的几何平均值和在夜间排出到尿布上的量为120nmol / L和13.4 nmol。在二元逻辑回归分析中，使用杀虫剂，除草剂，驱虫喷雾剂和香料或除臭剂或除臭剂增加的曝光水平的几率比（或尿液浓度的5％）（ORS：2.1 -2.6）。接收器操作特性曲线分析显示，确定Zdap浓度和量是否超过其95百分位值的鉴别权，对于曝光相关行为的相应倾向分数（曲线0.72和0.74的面积）和考虑因素，较低食品选择和准备（0.60和0.67），比调查日拍摄的食品（0.89和0.91）。我们揭示了日本幼儿OP杀虫剂的曝光率。曝光相关行为的贡献以及食物选择的考虑和对暴露水平的准备可能小于食品的含量远远小于食品。

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