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Pathway-Centric Analysis of the TCGA - NSCLC Transcriptome Data Pertaining to Deceased Patients

机译：与已故患者有关的TCGA - NSCLC转录组数据的途径分析

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Lung cancer among other cancer types is the most prevalent disease with about 1.9 million new cases observed each year and ranks the fifth most common cause of death according to the World Health Organization. Of the two main subtypes of lung cancer, non-small cell lung carcinoma (NSCLC) accounts for the majority of all cases. The two major subtypes of NSCLC, lung squamous cell carcinoma and lung adenocarcinoma are extensively sampled as part of The Cancer Genome Atlas (TCGA) project. In this study, we took a pathway centric focus on the analysis of RNA-Seq data belonging to dead NSCLC patients involved in TCGA. We applied statistical tests comparing subgroups of patients based on varying clinical traits such as tumor pathologic staging and the total number of days passed from diagnosis till death for the subjected patients. We also compared the transcriptome of smokers and nonsmokers to gain insights about the effect of tobacco smoking history on the gene expression patterns of deceased NSCLC patients. Neuroactive ligand-receptor interaction pathway was overrepresented in patients who died at pathologic T2 stage as well as in those lung cancer patients who survived less than a year. Down-regulation of the signaling pathways such as retrograde endocannabinoid, Hippo, AGE-RAGE in diabetic complications, Wnt, and oxytocin was also striking in patients who survived shorter. We show concordant results with previous findings about the down-regulation of nitric oxide synthase in smokers. This study may encourage more focused analyses of the TCGA data with a potential to cast new perspectives onto lung cancer research.
机译：其他癌症类型中的肺癌是最普遍的疾病，每年观察到约190万个新病例，并根据世界卫生组织排名第五次最常见的死亡原因。在肺癌的两种主要亚型中，非小细胞肺癌（NSCLC）占所有病例的大多数。 NSCLC，肺鳞状细胞癌和肺腺癌的两个主要亚型作为癌症基因组地图集（​​TCGA）项目的一部分被广泛地取样。在这项研究中，我们采用了一道以中心为中心，重点分析属于参与TCGA的死亡NSCLC患者的RNA-SEQ数据。我们应用基于不同临床特征的患者亚组的统计试验，例如肿瘤病理分期，并且从诊断到受到的患者死亡的天数。我们还比较了吸烟者和非吸烟者的转录组，以获得关于烟草吸烟病史对已故NSCLC患者基因表达模式的效果的见解。神经活性配体 - 受体相互作用途径过度呈现，在病理到病理T2阶段，以及在不到一年的肺癌患者中死亡。在较短的患者中，患有逆行内突植物，河马，患有糖尿病并发症的年龄愤怒，WNT和催产素等信号传导途径的下调也显着。我们展示了关于吸烟者中一氧化氮合酶的下定调节的先前发现的一致结果。本研究可以鼓励更多的重点分析TCGA数据，其潜力将新的视角施放到肺癌研究中。

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