BioMEMS applied to the development of cell-based bioassay systems,

机译：BioMEMS应用于基于细胞的生物测定系统的开发，

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Abstract: Biological applications of MEMS technology (bioMEMS) is of increasing interest in the development of miniature and portable instrumentation for cell-based microassays and sensor applications. A major bioMEMS challenge is the physical incorporation of living cells into sensors and diagnostic devices and creation of the environmental conditions conducive for organization of differentiated cells into tissue-like structures. Our work towards these goals is illustrated by a tissue-based bioassay system we are developing based on a miniature cross-flow bioreactor constructed from of an array of cell-filled microchannels integrated into an environmentally-controlled polymer microfluidics manifold. We describe our microchannel array and manifold manufacturing methods and report on the in vitro culture of cell populations in the bioreactor. !18

机译：摘要：MEMS技术（bioMEMS）的生物应用对于基于细胞的微测定法和传感器应用的微型便携式仪器的开发越来越感兴趣。生物MEMS的主要挑战是将活细胞物理整合到传感器和诊断设备中，并创造有利于将分化细胞组织成组织状结构的环境条件。我们正在基于微型错流生物反应器开发的基于组织的生物测定系统说明了我们为实现这些目标而开展的工作，该反应器由整合到环境控制的聚合物微流体歧管中的一系列充满细胞的微通道构成。我们描述了我们的微通道阵列和多方面的制造方法，并报告了生物反应器中细胞群体的体外培养。！18

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《Micro- and Nanotechnology for Biomedical and Environmental Applications》|2000年|p.76-87|
会议地点 San Jose CA(US)
作者
Colin J. Brenan; Massachusetts Institute of Technology; Cambridge; MA; USA; Karel Domansky; Massachusetts Institute of Technology; Cambridge; MA; USA; Petra Kurzawski; Massachusetts Institute of Technology; Cambridge; MA; USA; Linda G. Griffith; Massachus;
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机译：开发更新的方法，用于分离和鉴定源自能源的复杂混合物中的某些成分，并通过生物测定系统测定其生物活性。最后总结，

BioMEMS applied to the development of cell-based bioassay systems,

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