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首页> 外文会议>Microfluidics, bioMEMS, and medical microsystems XI >Selecting and designing with the right thermoplastic polymer for your microfluidic chip: a close look into cyclo-olefin polymer
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Selecting and designing with the right thermoplastic polymer for your microfluidic chip: a close look into cyclo-olefin polymer

机译：为您的微流控芯片选择合适的热塑性聚合物并进行设计：深入研究环烯烃聚合物

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摘要

Engineers who are developing microfluidic devices and bioMEMs for life science applications have many aspects to consider when selecting the proper base materials for constructing a device. While glass and polydimethylsiloxane (PDMS) are the staple materials for proof-of-concept and prototype chip fabrication, they are not a feasible solution for commercial production due to their slow, labor-intensive production rate. Alternatively, a molded or extruded thermoplastic solution can deliver the precision, consistency, and high volume capability required for commercial scale production. Traditional thermoplastics, such as polymethylmethacrylate (PMMA), polycarbonate (PC), and polystyrene (PS), are well known by development engineers in the bioscience community; however, cyclo-olefin polymer (COP), a relative newcomer in the world of plastics, is gaining increasing attention for use in microfluidic devices due to its unique balance of key properties compared to conventional thermoplastics. In this paper, we provide a comprehensive look at the properties which make COP an excellent candidate for providing the flow cell support and reagent storage functions in microfluidic assays. We also explore the processing attributes and capabilities of COP resin and film which are crucial for manufacturing high-performance microfluidic devices.
机译：为生命科学应用开发微流控设备和bioMEM的工程师在选择合适的基础材料来构建设备时要考虑许多方面。尽管玻璃和聚二甲基硅氧烷（PDMS）是概念验证和原型芯片制造的主要材料，但由于它们的生产速度慢，劳动强度大，因此不适用于商业生产。可替代地，模制或挤出的热塑性溶液可以提供商业规模生产所需的精度，一致性和高容量能力。传统的热塑性塑料，例如聚甲基丙烯酸甲酯（PMMA），聚碳酸酯（PC）和聚苯乙烯（PS），是生物科学界的开发工程师所熟知的。然而，由于环烯烃聚合物（COP）与常规热塑性塑料相比，其关键性能的独特平衡，使得环烯烃聚合物（COP）在塑料领域相对较新，正越来越引起人们对微流体设备使用的关注。在本文中，我们全面介绍了使COP成为在微流控分析中提供流通池支持和试剂存储功能的出色候选者的特性。我们还将探讨COP树脂和薄膜的加工属性和功能，这对于制造高性能微流控设备至关重要。

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