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首页> 外文会议>Microfluidics, BioMEMS, and Medical Microsystems V; Proceedings of SPIE-The International Society for Optical Engineering; vol.6465 >Nanoparticle analysis using microscale field flow fractionation
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Nanoparticle analysis using microscale field flow fractionation

机译：使用微尺度场流分馏的纳米颗粒分析

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Microscale electrical field flow fractionation (FFF) has shown significant progress since it was first reported in early 1997. The first electrical FFF systems were lucky to function for more than a few days and generated only minimal levels of retention and separation, while current systems now easily function for years and can generate multicomponent nanoparticle separations. A variety of microscale FFF systems have now been reported including: multiple versions of normal electrical FFF (E1FFF), cyclical electrical FFF (using oscillating fields), dielectrophoretic FFF, thermal FFF, and a combined thermal-electric FFF channel. Related microscale electrical SPLITT systems have also been demonstrated. Microscale E1FFF systems have been used to analyze and separate nanoparticles, DNA, proteins, cells, viruses, liposomes, large polymers, and other materials. E1FFF clearly improves upon system miniaturization due to the reduction in sample and carrier volumes, analysis times and more notably an increase in the separation resolution with a reduction in analysis times. Other advantages of miniaturized FFF include: parallel processing with multiple separation channels, batch fabrication with reduced costs, high quality manufacturing, and potentially disposable systems. Additionally, the possibility of on-chip sample injection, detection and signal processing favors the microfabrication of FFF systems.
机译：自从1997年初首次报道以来，微尺度电场流分级分离（FFF）就显示出了重大进展。第一个电子FFF系统幸运地运行了几天多，并且仅产生了最低限度的保留和分离，而现在的系统易于使用多年，并且可以产生多组分纳米颗粒分离。现在已经报道了多种微型FFF系统，包括：普通电子FFF（E1FFF）的多种版本，循环电子FFF（使用振荡场），介电泳FFF，热FFF和热电FFF组合通道。相关的微型电气SPLITT系统也得到了证明。微型E1FFF系统已用于分析和分离纳米颗粒，DNA，蛋白质，细胞，病毒，脂质体，大型聚合物和其他材料。由于减少了样品和载体的体积，缩短了分析时间，并且尤其是分离分辨率的提高以及分析时间的减少，E1FFF明显改善了系统的尺寸。小型FFF的其他优势包括：具有多个分离通道的并行处理，降低成本的批量制造，高质量制造以及潜在的一次性系统。此外，片上样品注入，检测和信号处理的可能性有利于FFF系统的微细加工。

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