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首页> 外文会议>Microfluidics, BioMEMS, and Medical Microsystems V; Proceedings of SPIE-The International Society for Optical Engineering; vol.6465 >A Simple Planar Micromixer with Low Pressure Drop For Disposable Lab-on-a-Chip (LOC) Systems
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A Simple Planar Micromixer with Low Pressure Drop For Disposable Lab-on-a-Chip (LOC) Systems

机译：适用于一次性芯片实验室（LOC）系统的具有低压降的简单平面微型混合器

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摘要

In this work the design and fabrication of a novel passive microfluidic mixer capable of achieving mixing in shorter distances and lower Reynolds numbers (Re) is reported. Passive mixers typically rely on the channel geometry to mix fluids, and many previously reported designs work efficiently only at moderate to high Re and are often difficult to fabricate as they incorporate complex 3-D structures within the channel. The mixer design discussed in this work achieves good mixing at low Re, has planar geometry and thus is simpler to fabricate and integrate with existing lab-on-a-chip (LOC) technologies. The design incorporates triangular notches patterned along the channel walls to laminate the flow, thus enhancing mixing. Numerical and experimental studies to determine the effect of the notch dimensions and placement within the microchannel were carried out to optimize the mixing performance. Results show that the final mixer design is efficient at mixing fluids at low Re. The mixer is fabricated in polydimethylsiloxane (PDMS) bonded to glass slides and tested using fluorescence dyes. Results show that the new design exhibit complete mixing at Re < 0.1 within 7 mm and thus will benefit a wide range of LOC applications where space is limited.
机译：在这项工作中，报道了一种新型无源微流体混合器的设计和制造，该混合器能够在较短的距离和较低的雷诺数（Re）下实现混合。无源混合器通常依赖于通道的几何形状来混合流体，并且许多先前报道的设计仅在中等至高Re下才能有效地工作，并且由于在通道内结合了复杂的3-D结构，因此通常难以制造。这项工作中讨论的混合器设计可在低Re下实现良好的混合，具有平面几何形状，因此更易于制造并与现有的芯片实验室（LOC）技术集成。该设计结合了沿槽壁构图的三角形凹口，以层压流动，从而增强了混合效果。进行了数值和实验研究以确定缺口尺寸和在微通道中的位置的影响，以优化混合性能。结果表明，最终的混合器设计可以有效地混合低Re的流体。该混合器由粘合在载玻片上的聚二甲基硅氧烷（PDMS）制成，并使用荧光染料进行了测试。结果表明，新设计在7 mm的Re <0.1范围内显示出完全混合，因此将有益于空间有限的各种LOC应用。

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