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首页> 外文会议>Micro/Nanoscale Heat Transfer International Conference 2008 >ULTRASENSITIVE MICRO/NANOSCALE RESISTIVE PULSE SENSORS BY INTEGRATING FLUIDIC DEVICES WITH MOSFETS
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ULTRASENSITIVE MICRO/NANOSCALE RESISTIVE PULSE SENSORS BY INTEGRATING FLUIDIC DEVICES WITH MOSFETS

机译：通过将流体器件与MOSFET集成在一起，实现超灵敏的微/纳米电阻脉冲传感器

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摘要

Nanofluidic sensors have been developed over the past decade and demonstrated the capability of sensing single DNA molecules. One class of nanofluidic devices is based on the resistive pulse sensing technique and a modulation of the baseline ionic current can be observed when molecules are translocated through the sensing nanopore or nanochannel. In this scheme, the ionic current modulation is approximately the same as the channel resistance modulation, requiring the channel size be comparable to the molecules to be detected. In this paper, we present a new sensing scheme to detect the translocation of particles through a fluidic channel, which amplifies the resistance modulation by 40-80 times. The device connects the gate of a MOSFET with a fluidic circuit and monitors the drain current modulation of the MOSFET to detect particles, instead of directly monitoring the ionic current through the fluidic channel. The minimum volume ratio detected is 0.006%, about ten times smaller than the lowest detectable volume ratio reported in the literature by using the resistive pulse sensing technique. Although at current stage the device is only fabricated at microscale level, we envision that the same scheme can be applied in nanofluidic devices for single molecule detection.
机译：纳米流体传感器在过去的十年中得到了发展，并展示了检测单个DNA分子的能力。一类纳米流体设备基于电阻脉冲传感技术，当分子通过传感纳米孔或纳米通道移位时，可以观察到基线离子电流的调制。在此方案中，离子电流调制与通道电阻调制大致相同，要求通道大小与要检测的分子相当。在本文中，我们提出了一种新的传感方案来检测粒子通过流体通道的移位，从而将电阻调制放大了40-80倍。该器件将MOSFET的栅极与流体电路相连，并监视MOSFET的漏极电流调制以检测颗粒，而不是直接监视通过流体通道的离子电流。通过使用电阻式脉冲传感技术，检测到的最小体积比为0.006％，比文献中报道的最低可检测体积比小约十倍。尽管在现阶段该设备仅在微尺度水平上制造，但我们设想可以将相同的方案应用于纳米流体设备中进行单分子检测。

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