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首页> 外文会议>NAMS(North American Membrane Society) 17th Annual Meeting >Chiral Separation by Enantioselective Inclusion Complexation-Organic Solvent Nanofiltration
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Chiral Separation by Enantioselective Inclusion Complexation-Organic Solvent Nanofiltration

机译：对映选择性包合络合-有机溶剂纳滤的手性分离

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摘要

Enantioselective inclusion complexation (EIC) is a promising technique for chiral resolutions which, since it is not restricted to proton transfer interactions, can in principle be used to resolve compounds with almost any functional group. However an outstanding difficulty with EIC is the separation of enantiomer from the enantioenriched solid complex, typically performed by distillation. This limits EIC to enantiomers with appreciable volatility, and even for these it would be difficult to operate at large-scale due to high temperature distillation, with concomitant problematic heat transfer and vacuum conditions. Here we report for the first time a novel enantioseparation process which combines the highly enantioselective nature of inclusion complexation with the subsequent separation of enantiomers from a chiral host using solvent decomplexation and organic solvent nanofiltration (OSN).
机译：对映选择性包合络合（EIC）是一种有前途的拆分技术，由于它不限于质子转移相互作用，因此原则上可以用于拆分几乎任何官能团的化合物。然而，EIC的突出困难是通常通过蒸馏来进行对映体与对映体富集的固体复合物的分离。这将EIC限制在具有相当挥发性的对映异构体上，即使如此，由于高温蒸馏，伴随传热和真空条件的问题，很难大规模操作对映异构体。在这里，我们首次报道了一种新颖的对映体分离过程，该过程结合了包合物的高度对映选择性，并随后使用溶剂分解和有机溶剂纳滤（OSN）从手性宿主中分离出对映体。

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