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首页> 外文会议>Nanobiosystems: Processing, characterization, and applications II >Stretching of (DNA/functional molecules) complex between electrodes towards DNA molecular wire
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Stretching of (DNA/functional molecules) complex between electrodes towards DNA molecular wire

机译：电极之间的（DNA /功能分子）复合物向DNA分子线的伸展

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DNA/functional molecules such as (Ru(bpy)_3~(2+) complex, conducting polymer etc.) complex was prepared to study molecular structure and I-V characteristics towards DNA molecular wire. For example, Ru(bpy)_3~(2+) was associated with duplex of DNA by not only electrostatic interaction but also intercalation in the aqueous solution. Single-molecular structure of DNA/Ru(bpy)_3~(2+) complex was analyzed with AFM. We found a network structure of DNA/Ru(bpy)_3~(2+) complex on the mica substrate, which is similar to native DNA. The height of DNA/Ru(bpy)_3~(2+) complex on the mica substrate was ranging from 0.8 to 1.6 nm, which was higher than the naked DNA (0.5-1.0 nm). This indicates that single-molecular DNA/Ru(bpy)_3~(2+) complex also connects to each other to form network structure on a mica substrate. In order to stretch DNA complex between electrodes, we employed high frequency and high electric field stretching method proposed by Washizu et al. We stretched and immobilized DNA single molecules between a pair of electrodes and its structures were analyzed with AFM technique. The I-V characteristics of DNA single molecules between electrodes were improved by the association of functional molecules with DNA. The molecular structure and I-V characteristics of DNA complex were discussed.
机译：制备了DNA /功能分子，如（Ru（bpy）_3〜（2+）配合物，导电聚合物等）配合物，以研究分子结构和对DNA分子线的IV特性。例如，Ru（bpy）_3〜（2+）不仅通过静电相互作用而且通过在水溶液中的嵌入与DNA的双链体缔合。用原子力显微镜对DNA / Ru（bpy）_3〜（2+）复合物的单分子结构进行了分析。我们发现云母底物上的DNA / Ru（bpy）_3〜（2+）复合物的网络结构类似于天然DNA。云母底物上的DNA / Ru（bpy）_3〜（2+）复合物的高度为0.8-1.6 nm，高于裸DNA（0.5-1.0 nm）。这表明单分子DNA / Ru（bpy）_3〜（2+）复合物也相互连接，在云母基底上形成网络结构。为了拉伸电极之间的DNA复合物，我们采用了Washizu等人提出的高频和高电场拉伸方法。我们在一对电极之间拉伸并固定了DNA单分子，并通过AFM技术对其结构进行了分析。功能分子与DNA的结合改善了电极之间DNA单分子的I-V特性。讨论了DNA复合物的分子结构和IV特征。

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