Spectral investigations on the binding of DNA-CTMA complex with Tetrameric Copper Phthalocyanines

机译：DNA-CTMA复合物与四聚酞菁铜结合的光谱研究

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The binding of DNA-CTMA (Deoxyribonucleic acid-cetyltrimethylammonium) complex with two tetrameric Copper Phthalocyanine (CuPc) systems, substituted with carboxylic acid (CuPc-COOH) and derivatized further as an imidazolium salt (CuPc-COOR), was investigated in dimethylsulfoxide (DMSO) solutions using UV/Visible Spectroscopy. Absorbance changes at 685 run (Q band of the CuPc) were monitored as a function of DNA-CTMA added to the dye solution and stock concentrations of DNA-CTMA in DMSO were varied to facilitate observation of the full binding process. Our findings indicated that while binding with DNA-CTMA was more well-defined in the case of CuPc-COOH, the binding profile of the CuPc-COOR showed initial growth followed by decay in its Q-band absorbance which was indicative of a more complex binding mechanism involving the dye and DNA-CTMA. Preliminary findings from photophysical studies involving the CuPc tetramers and DNA-CTMA are also discussed in this paper.

机译：在二甲亚砜中研究了DNA-CTMA（脱氧核糖核酸-鲸蜡基三甲基铵）配合物与两个四聚酞菁铜（CuPc）系统的结合，并用羧酸（CuPc-COOH）取代并进一步衍生为咪唑鎓盐（CuPc-COOR）。 DMSO）解决方案，使用紫外/可见光谱。监测685nm（CuPc的Q谱带）处的吸光度变化，作为添加到染料溶液中的DNA-CTMA的函数，并改变DMSO中DNA-CTMA的储备浓度，以利于观察整个结合过程。我们的研究结果表明，在CuPc-COOH的情况下，与DNA-CTMA的结合更为明确，但CuPc-COOR的结合曲线显示出初始生长，随后其Q波段吸光度下降，这表明更为复杂。染料和DNA-CTMA的结合机制。本文还讨论了涉及CuPc四聚体和DNA-CTMA的光物理研究的初步发现。

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《Nanobiosystems: Processing, characterization, and applications VI》|2013年|88170E.1-88170E.10|共10页
会议地点 San Diego CA(US)
作者
Narayanan Venkat; Joy E. Haley; Rachel Swiger; Lei Zhu; Xiaoliang Wei; Fahima Ouchen; James G. Grote;
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作者单位

Air Force Research Laboratories, Wright-Patterson AFB, OH 45433,University of Dayton Research Institute, Dayton, OH 45469;

Air Force Research Laboratories, Wright-Patterson AFB, OH 45433;

Air Force Research Laboratories, Wright-Patterson AFB, OH 45433,Southwestern Ohio Council of Higher Education (SOCHE), Dayton, OH 45420;

Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland OH 44106;

Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland OH 44106;

Air Force Research Laboratories, Wright-Patterson AFB, OH 45433,University of Dayton Research Institute, Dayton, OH 45469;

Air Force Research Laboratories, Wright-Patterson AFB, OH 45433;

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正文语种 eng
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关键词
Binding; DNA-CTMA; Copper Phthalocyanine (CuPc) tetramers; UV-Visible Spectroscopy;

机译：捆绑; DNA-CTMA;酞菁铜（CuPc）四聚体;紫外可见光谱;

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Spectral investigations on the binding of DNA-CTMA complex with Tetrameric Copper Phthalocyanines

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