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Ultrasensitive Biomolecular Assays with Amplifying Nanowire FET Biosensors

机译:具有放大纳米线FET生物传感器的超灵敏生物分子测定

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In this paper, we review our recent development and validation of the ultrasensitive electronic biomolecular assays enabled by our novel amplifying nanowire field-effect transistor (nwFET) biosensors. Our semiconductor nwFET biosensor platform technology performs extreme proximity signal amplification in the electrical domain that requires neither labeling nor enzymes nor optics. We have designed and fabricated the biomolecular assay prototypes and developed the corresponding analytical procedures. We have also confirmed their analytical performance in quantitating key protein biomarker in human serum, demonstrating an ultralow limit of detection and concurrently high output current level for the first time.
机译:在本文中,我们回顾了我们最近通过新型新型纳米线场效应晶体管(nwFET)生物传感器实现的超灵敏电子生物分子测定技术的开发和验证。我们的半导体nwFET生物传感器平台技术在不需要标签,不需要酶或不需要光学元件的电域中执行极端接近信号放大。我们已经设计和制造了生物分子分析的原型,并开发了相应的分析程序。我们还证实了它们在定量人血清中关键蛋白质生物标志物方面的分析性能,首次证明了超低检测限和同时高输出电流水平。

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