The micropatterns of glutaraldehyde-crosslinked gelatin as ECM for attachment of tumor cells

机译：戊二醛交联明胶作为细胞外基质的微模式

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Use of this work proposes a novel technique to induce the attachment of tumor cells to the micropatterns of glutaraldehyde (GA)-crosslinked gelatin. It provides another method to crosslink gelatin other than using the photo-sensitizing agents or selective GA-crosslinked technique. The micropatterns of GA-crosslinked gelatin are fabricated by O₂ plasma etching process. This novel technique can ensure the degree of crosslink, prevent the over-crosslink from pattern deformation and enhance the adhesion between the gelatin and glass slide. The best spatial resolution of the micro gelatin bases can be reached to 2 mum. The micropatterns of GA-crosslinked gelatin can still be made successfully by the conventional photolithography. The much less toxic and more biocompatible approaches of strengthening the gelatin microstructures can be developed according to the idea herein.

机译：使用这项工作提出了一种新技术，以诱导肿瘤细胞附着到戊二醛（GA）交联的明胶的微观模式。除了使用光敏剂或选择性GA交联技术外，它还提供了另一种交联明胶的方法。通过O _{2 等离子体刻蚀工艺制备了GA交联明胶的微图案。这种新技术可以确保交联度，防止过度交联引起图案变形，并增强明胶和载玻片之间的附着力。微型明胶基质的最佳空间分辨率可以达到2微米。通过传统的光刻法仍可以成功地制备GA交联的明胶的微图案。可以根据本文的思想开发出毒性更小且生物相容性更高的增强明胶微结构的方法。}

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《Nano/Micro Engineered and Molecular Systems, 2009. NEMS 2009》|2009年|314-318|共5页
会议地点 Shenzhen(CN);Shenzhen(CN)
作者
Yu-Cheng Ou; Chih-Wen Hsu; Lung-Jieh Yang; Hsieh-Cheng Han; Yi-Wen Liu; Chien-Yuan Chen;
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Dept. of Mech. Electro-Mech. Eng., Tamkang Univ., Tamsui;

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关键词
adhesion; biochemistry; biological techniques; cancer; cellular biophysics; deformation; gelatin; molecular biophysics; photochemistry; photolithography; tumours; ECM; GA-crosslinked gelatin fabrication; adhesion enhancement; conventional photolithography; extracellular matrix protein; glutaraldehyde-crosslinked gelatin micropattern; pattern deformation; photo-sensitizing agent; plasma etching process; selective GA-crosslinked technique; spatial resolution; tumor cell attachment; Attachment; Glutaraldehyde; Tumor cells;

机译：粘附;生物化学;生物学技术;癌症;细胞生物物理学;变形;明胶;分子生物物理学;光化学;光刻;肿瘤; ECM; GA交联的明胶制造;粘附力增强;常规光刻;细胞外基质蛋白;戊二醛交联的明胶微图案;图案变形;光敏剂;等离子体刻蚀工艺;选择性GA交联技术;空间分辨率;肿瘤细胞附着;附着;戊二醛;肿瘤细胞;

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1. Comparison of selective attachment and growth of smooth muscle cells on gelatin- and fibronectin-coated micropatterns [J] . Li M, Cui T, Mills DK, Journal of nanoscience and nanotechnology . 2005,第11期

机译：在明胶和纤连蛋白包被的微图案上平滑肌细胞的选择性附着和生长的比较
2. Attachment Of Tumor Cells To The Micropattems Of Glutaraldehyde (ga)-crosslinked Gelatin [J] . Yu-Cheng Ou, Chih-Wen Hsu, Lung-Jieh Yang, Sensors and materials . 2008,第8期

机译：肿瘤细胞对戊二醛（ga）交联的明胶的微模式的附着。
3. Effects of ECM protein micropatterns on the migration and differentiation of adult neural stem cells [J] . Sunghoon Joo, Joo Yeon Kim, Eunsoo Lee, Scientific reports. . 2015,第1期

机译：ECM蛋白微模式对成年神经干细胞迁移和分化的影响
4. The Micropatterns of Glutaraldehyde-crosslinked Gelatin as ECM for Attachment of Tumor Cells [C] . Yu-Cheng Ou, Chih-Wen Hsu, Lung-Jieh Yang, IEEE International Conference on Nano/Micro Engineered and Molecular Systems . 2009

机译：戊二醛 - 交联明胶作为ECM的Micropatterns，用于附着肿瘤细胞
5. Attachment and detachment of circulating tumor cells in an antibody-functionalized microsystem [D] . Cheung, Siu Lun. 2009

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6. Micropatterning of ECM Proteins on Glass Substrates to Regulate Cell Attachment and Proliferation [O] . Omid G. Alamdari, Ehsan Seyedjafari, Masoud Soleimani, 2013

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7. Micropatterning Decellularized ECM as a Bioactive Surface to Guide Cell Alignment, Proliferation, and Migration [O] . Emily Cady, Jacob A. Orkwis, Rachel Weaver, 2020

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The micropatterns of glutaraldehyde-crosslinked gelatin as ECM for attachment of tumor cells

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