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Fabrication and characterization of thermo-responsive gold nanorod assemblies

机译：热响应性金纳米棒组件的制备和表征

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摘要

Advancements in nanotechnology sensors have aided in the detection of subtle, but significant cellular deviations that may mark certain stages of diseases. Gold nanorods (GNRs) are often studied for this purpose due to their tunable optical properties and ease in surface functionalization. The absorption properties of GNRs are governed by the localized surface plasmon resonance (LSPR), which strongly depends on the GNR's aspect ratio and on interparticle interactions. By controlling the coupling of nearby rods, a sensor can be created to respond to temperature fluctuations in the local environment. Here, we fabricated thermo-responsive gold nanorod assemblies by conjugating GNRs in end-to-end or side-by-side configurations using Poly(N-isopropyl acrylamide) (PNIPAM). End-to-end assemblies were fabricated through mixture of GNRs and PNIPAM in DI water. GNRs and PNIPAM were combined in DI water and dimethylformamide (DMF) under sonication to achieve side-by-side configuration. The optical absorption of the assemblies was measured by UV-Visible spectroscopy at different temperatures. As the temperature increased, the polymer contracted and initiated plasmon coupling between the GNRs. The optical spectrum experienced a blue- or red-shift for side-by-side or end-to-end configurations, respectively. Spectral tunability reversal was observed when cooled. Experimental results were verified by finite-difference time-domain (FDTD) calculations, which demonstrated spectral shifts under similar parameters. We present methods for fabrication of thermo-responsive gold nanorods for use as a local thermal nanosensor.
机译：纳米技术传感器的进步有助于检测细微但明显的细胞偏差，这些疾病可能标志着疾病的某些阶段。金纳米棒（GNR）由于其可调的光学特性和易于表面功能化而经常为此目的而进行研究。 GNR的吸收特性受局部表面等离振子共振（LSPR）的控制，LSPR很大程度上取决于GNR的长宽比和粒子间的相互作用。通过控制附近杆的耦合，可以创建传感器以响应本地环境中的温度波动。在这里，我们通过使用聚（N-异丙基丙烯酰胺）（PNIPAM）端对端或并排配置共轭GNR来制造热响应性金纳米棒组件。端到端组件是通过在去离子水中混合GNR和PNIPAM制成的。在超声处理下，将GNR和PNIPAM在去离子水和二甲基甲酰胺（DMF）中合并，以达到并排配置。通过在不同温度下的UV-可见光谱法测量组件的光学吸收。随着温度升高，聚合物收缩并引发GNR之间的等离激元偶联。对于并排或端对端配置，光谱分别经历了蓝移或红移。冷却时观察到光谱可调性反转。通过有限差分时域（FDTD）计算验证了实验结果，该计算证明了相似参数下的光谱漂移。我们提出了制造用作局部热纳米传感器的热敏金纳米棒的方法。

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  • 会议地点 San Francisco(US)
  • 作者

    Gilbert Bustamante; Katherine Carrizales; Frank DeLuna; Nicolas Large; Jing Yong Ye;

  • 作者单位

    Department of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA;

    Department of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA;

    Department of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA;

    Department of Physics and Astronomy, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA;

    Department of Biomedical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Gold nanorods; PNIPAM; Plasmons; Thermal Sensor;

    机译：金纳米棒； PNIPAM；等离子温度传感器;

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