Surface-Enhanced Raman Scattering (SERS) for Detection of Phenylketonuria for Newborn Screening

机译：表面增强拉曼散射（SERS）用于检测苯丙酮尿症以进行新生儿筛查

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Diagnosis of Phenylketonuria (PKU) in newboms is important because it can potentially help prevent mental retardation since it is treatable by dietary means. PKU results in phenylketonurics having phenylalanine levels as high as 2 mM whereas the normal upper limit in healthy newborns is 120 uM. To this end, we are developing a microfluidic platform integrated with a SERS substrate for detection of high levels of phenylalanine. We have successfully demonstrated SERS detection of phenylalanine using various SERS substrates fabricated using nanosphere lithography, which exhibit high levels of field enhancement. We show detection of SERS at clinically relevant levels.

机译：对新出生的苯丙酮尿症（PKU）的诊断很重要，因为它可以通过饮食手段治疗，因此有可能帮助预防智力低下。 PKU导致苯酮尿酸类药物的苯丙氨酸水平高达2 mM，而健康新生儿的正常上限为120 uM。为此，我们正在开发与SERS底物集成在一起的微流体平台，用于检测高水平的苯丙氨酸。我们已经成功地展示了使用纳米球面光刻技术制造的各种SERS基底对苯丙氨酸的SERS检测，这些基底表现出高水平的场增强。我们显示在临床相关水平上检测到SERS。

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《Nanoscale imaging, sensing, and actuation for biomedical applications XI》|2014年|89540R.1-89540R.7|共7页
会议地点 San Francisco CA(US)
作者
M. Javanmard; R. W. Davis;
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作者单位

Stanford Genome Technology Center, Stanford University, 855 S. California Ave, Palo Alto, CA 94304;

Stanford Genome Technology Center, Stanford University, 855 S. California Ave, Palo Alto, CA 94304;

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正文语种 eng
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关键词
Microfluidic Sample Preparation; Dielectrophoresis; Surface Enhanced Raman Scattering; Phenylketonuria;

机译：微流体样品制备；介电泳;表面增强拉曼散射；苯丙酮尿症;

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Surface-Enhanced Raman Scattering (SERS) for Detection of Phenylketonuria for Newborn Screening

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