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首页> 外文会议>Nanotechnology 2009 : Technical proceedings >Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent
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Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent

机译：交联条件对仿生纤维复合材料动脉内当量力学和生物学性能的影响

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摘要

Biomechanical properties of a vascular graft scaffold can be optimized by studying the effect of genipin crosslinker. Collagen-based scaffolds were prepared from a mixture of rat tail collagen, chitosan and bovine aortic elastin and crosslinked with varying concentrations of genipin. Biomechanical testing results showed that the linear modulus of the uncrosslinked samples had the least modulus (84.75 kPa ± 26.45 kPa) while crosslinked scaffolds exhibited much higher linear moduli. Similar increase was observed for the ultimate strength. However, an un-crosslinked sample exhibited the best compatibility with arterial smooth muscle cells (SMC) because increase in concentration of genipin decreased SMC contraction. These studies show superior biomechanical properties can be achieved by balancing mechanical and biological properties of the scaffold with an appropriate crosslinking condition.
机译：可以通过研究Genipin交联剂的作用来优化血管移植支架的生物力学性能。由大鼠尾部胶原，壳聚糖和牛主动脉弹性蛋白的混合物制备基于胶原的支架，并与不同浓度的京尼平交联。生物力学测试结果表明，未交联样品的线性模量具有最小的模量（84.75 kPa±26.45 kPa），而交联支架的线性模量更高。观察到极限强度也有类似的增加。但是，未交联的样品表现出与动脉平滑肌细胞（SMC）的最佳相容性，因为京尼平浓度的增加降低了SMC的收缩。这些研究表明，可以通过在适当的交联条件下平衡支架的机械和生物学特性来实现卓越的生物力学特性。

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  • 会议地点 Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston TX(US);Houston
  • 作者

    K. Madhavan; D. Belchenko; W. Tan;

  • 作者单位

    Department of Mechanical Engineering, University of Colorado, Boulder, CO, USA;

    Department of Pediatric Cardiology, University of Colorado Health Sciences Center Aurora, CO, USA;

    Department of Mechanical Engineering, University of Colorado, Boulder, CO, Department of Pediatric Cardiology, University of Colorado Health Sciences Center, Aurora, CO, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 特种结构材料;
  • 关键词

    collagen; genipin; strength; biocompatibility; smooth muscle cell;

    机译：胶原;京尼平;强度;生物相容性平滑肌细胞;

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