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首页> 外文会议>Nanotechnology 2009 : Technical proceedings >Size matters: The outer diameter of multiwalled carbon nanotubes (MWCNTs) affects gene expression in female fathead minnows (Pimephales promelas)
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Size matters: The outer diameter of multiwalled carbon nanotubes (MWCNTs) affects gene expression in female fathead minnows (Pimephales promelas)

机译：大小很重要：多壁碳纳米管（MWCNT）的外径会影响雌性黑头min鱼（Pimephales promelas）中的基因表达

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摘要

We used oligonucleotide microarrays to examine the gene expression patterns in liver, gonad and gill tissues from adult female fathead minnows (FHM, Pimephales promelas) exposed to two different sizes (< 8 nm and 50-80 nm outer diameter) and multiple doses of multiwalled carbon nanotubes (MWCNTs) under aerated static renewal conditions. We observed significant (p≤0.05 and fold change ≥2) differential gene expression in each of the three tissues due both to size and exposure dose. All three tissues express more genes (regardless of dose) after exposure to the larger size MWCNTs. The liver shows a higher percentage of genes up-regulated in response to exposure to MWCNTs regardless of size. The ovary shows more genes down-regulated after exposure to both sizes. Forty-eight genes were differentially expressed in gills for both sizes of MWCNT although significant histopathological results (fused and shortened gill lamellae) were only observed for the smaller MWCNTs. We conclude that, under some conditions, size does matter in regard to MWCNTs.
机译：我们使用寡核苷酸微阵列检查了成年雌性黑头min鱼（FHM，Pimephales promelas）暴露于两种不同大小（外径<8 nm和50-80 nm）和多剂量多层壁的肝脏，性腺和g组织中的基因表达模式。充气静态更新条件下的碳纳米管（MWCNT）。我们观察到由于大​​小和暴露剂量，在三个组织中的每个组织中均存在显着（p≤0.05，且倍数变化≥2）差异基因表达。暴露于较大尺寸的MWCNT后，所有三个组织均表达更多的基因（不考虑剂量）。不论大小，肝脏响应暴露于MWCNTs都显示出更高百分比的上调基因。卵巢在暴露于两种大小后显示出更多的基因下调。尽管只有较小的MWCNT才观察到显着的组织病理学结果（融合和缩短的ill片），但两种大小的MWCNT在g中差异表达了48个基因。我们得出的结论是，在某些条件下，尺寸对于MWCNT确实很重要。

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