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首页> 外文会议>Nanotechnology amp; applications >SYNTHETIC WATER-SOLUBLE POLYMERS IN SELF-ORGANIZING NANOSYSTEMS FOR IMMYNOLOGY
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SYNTHETIC WATER-SOLUBLE POLYMERS IN SELF-ORGANIZING NANOSYSTEMS FOR IMMYNOLOGY

机译：免疫学的自组织纳米系统中的合成水溶性聚合物

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摘要

This work presents our results in application of water-soluble polymers in immunology-related areas: design of antigenic erythrocytic diagnosticums and adjuvants for production of hyperimmune serums. We found that long-chain polymeric acids (polymerization degree >6000) can give composite particles with erythrocytes and antigens. The resulting product works as diagnosticum in the reaction of passive haemagglutination. Introduction of hydrophobic or weakly basic imidazole units into polymer chain allows to decrease working concentration of the polymer to 0.01 mg/mL. New test-systems are more sensitive, reproducible and stable than the known analogs.rnTetrazole- and imidazole-containing polymers are active as immunologic adjuvants. Their complexes with antigens stimulate production of antibodies to diphtheria, encephalitis, hepatitis and chicken Marek's disease. The polymeric adjuvants provides 2-10 times higher antibody titers comparing with standard (complete Freund's adjuvant). Low polymer concentration (0.03-0.6 mg/mL) in adjuvant solutions gives rise to cheapness and high usability of the new adjuvants.rnThe distinguishing feature of the used polymers is their ability to give target products without covalent bonding with antigens. Formation of the polymer-antigen complexes and their self-organization proceeds by multiple cooperative hydrogen/ionic bonds.
机译：这项工作为水溶性聚合物在免疫学相关领域的应用提供了我们的研究成果：抗原性红细胞诊断菌和用于生产超免疫血清的佐剂的设计。我们发现，长链聚合酸（聚合度> 6000）可以使复合颗粒与红细胞和抗原结合。所得产物在被动血凝反应中起诊断作用。将疏水或弱碱性咪唑单元引入聚合物链中可将聚合物的工作浓度降低至0.01 mg / mL。新的测试系统比已知的类似物更灵敏，可重现和稳定。含四唑和咪唑的聚合物可作为免疫佐剂。它们与抗原的复合物刺激白喉，脑炎，肝炎和鸡马立克氏病抗体的产生。与标准（完全弗氏佐剂）相比，聚合物佐剂的抗体效价高2-10倍。佐剂溶液中的低聚合物浓度（0.03-0.6 mg / mL）带来了廉价和新佐剂的高可用性。使用的聚合物的显着特征是它们能够提供目标产物而不与抗原共价键合。聚合物-抗原复合物的形成及其自组织通过多个氢/离子协作键进行。

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