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PROFOUND IMPLICATIONS FOR BIOPHYSICS OF THE POLYMER THREADING A MEMBRANE TRANSITION

机译:聚合物对膜转变的生物物理学的深远影响

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摘要

There are 5 phase transitions unique to polymers. They are the: 1) helix to random-coil transition in polypeptides, DNA, and collagen, 2) polymer adsorption transition, 3) collapse transition, 4) equilibrium polymerization transition, and the 5) polymer threading a membrane transition (PTM). The derivation of the PTM transition contained here allows us to understand why the 5 phase transitions exist. The 5 transitions, plus the 5 phase transitions common to both polymers and non-polymeric material, plus the many couplings of these transitions to each other give in total 1023 a priori possible transitions. Three examples taken from the 45 a priori possible coupled pairs are described in the paper. They are the: 1) polymerization transition coupled to the isotropic to nematic liquid crystal transition, 2) helix to random-coil transition coupled to surface adsorption, and the 3) PTM transition coupled to the helix to random-coil transition. Three areas of future work are mentioned: a) study of the equilibrium, kinetic, and pattern formation aspects of the 10 phase transitions and their couplings b) self-assembly viewed as polymer phase transition phenomena, and c) a proof that all evolved life-forms must necessarily be polymeric. Finally two applications of the PTM transition are given: 1) interpretation of viral DNA injection into a cell as a PTM transition, and 2) the "going fishing" model of transport of material across a cell membrane.
机译:聚合物具有5种独特的相变。它们是:1)多肽,DNA和胶原蛋白中的螺旋到随机螺旋的转变,2)聚合物吸附转变,3)塌陷转变,4)平衡聚合转变,以及5)聚合物穿入膜转变(PTM)。这里包含的PTM转换的推导使我们能够理解为什么存在5个相变。 5个转变,加上聚合物和非聚合物材料共有的5个相转变,加上这些转变彼此之间的许多偶合,总共给了1023个先验的可能转变。本文描述了从45个先验可能的配对中选取的三个例子。它们是:1)与各向同性向向列相液晶转变相耦合的聚合转变,2)与表面吸附耦合的螺旋向无规卷曲转变,和3)与螺旋向无规转变相耦合的PTM转变。提到了未来工作的三个方面:a)研究10个相变及其耦合的平衡,动力学和模式形成方面b)自组装被视为聚合物相变现象,并且c)证明了所有演化寿命-形式必须是聚合的。最后给出了PTM转换的两种应用:1)将病毒DNA注入细胞作为PTM转换的解释,以及2)跨细胞膜运输物质的“进行捕鱼”模型。

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