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首页> 外文会议>NATO Advanced Research Workshop on Biological, Biophysical amp; Theoretical Aspects of Polymer Structure and Transport Jun 20-25, 1999 Bikal, Hungary >PHAGE DNA TRANSPORT ACROSS MEMBRANES
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PHAGE DNA TRANSPORT ACROSS MEMBRANES

机译：跨膜的DNA转运

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摘要

Phage nucleic acid transport is atypical among membrane transport and thus poses a fascinating problem: transport is unidirectional, and it concerns a unique molecule the size of which may represent 50 times that of the bacterium. The rate of DNA transport can reach values as high as 3,000 to 4,000 base pairs s~(-1). This raises many questions which will be addressed in this review. Is there a single mechanism of transport for all types of phage? How does the phage genome overcome the hydrophobic barrier of the host envelope? Is DNA transported as a free molecule or in association with proteins? Is such transport dependent on phage and/or host cell components? What is the driving force for transport? Data will be presented on tailed phage which are the most common type of phage, occurring in over 100 genera of bacteria and for which DNA transport has been the most extensively studied. We will show that it is possible to analyse these mechanisms both in vivo and in vitro by using biochemical as well as biophysical approaches.
机译：噬菌体核酸的运输在膜运输中是非典型的，因此提出了一个令人着迷的问题：运输是单向的，并且涉及一种独特的分子，其大小可能代表细菌的50倍。 DNA的传输速率可以达到s〜（-1）3,000至4,000个碱基对。这就提出了许多问题，本次审查将解决这些问题。所有噬菌体都有单一的运输机制吗？噬菌体基因组如何克服宿主包膜的疏水性屏障？ DNA是作为游离分子还是与蛋白质结合运输？这种运输是否依赖于噬菌体和/或宿主细胞成分？运输的驱动力是什么？将提供有关尾巴噬菌体的数据，这是最常见的噬菌体类型，存在于100多个细菌的属中，而DNA转运已被广泛研究。我们将显示通过使用生化方法以及生物物理方法，可以在体内和体外分析这些机制。

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