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首页> 外文会议>NATO Advanced Research Workshop on Biological, Biophysical amp; Theoretical Aspects of Polymer Structure and Transport Jun 20-25, 1999 Bikal, Hungary >POLYMER TRANSLOCATION THROUGH A 'COMPLICATED' PORE
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POLYMER TRANSLOCATION THROUGH A 'COMPLICATED' PORE

机译：通过“复杂的”孔进行聚合物移位

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摘要

Motivated by experiments in which a polynucleotide is driven through a pro-teinaceous pore by an electric field, we study the diffusive motion of a polymer threaded through a narrow channel with which it may have strong interactions. We show that there is a range of polymer lengths in which the system is approximately translationally invariant, and we develop a coarse-grained description of this regime. In contrast to previous models, this description holds even when some pore degrees of freedom do not remain equilibrated. General features of the distribution of times for the polymer to pass through the pore are then deduced. Finally, we consider more microscopic models and argue that the available data suggests a translocation mechanism involving coupling between the polymer backbone and other slow degrees of freedom.
机译：受实验驱动，其中多核苷酸被电场驱动通过蛋白网孔，我们研究了穿过狭窄通道的聚合物的扩散运动，该通道可能具有很强的相互作用。我们表明，在一定范围的聚合物长度中，该系统在翻译上几乎是不变的，并且我们对此方法进行了粗粒度的描述。与以前的模型相比，即使某些孔隙自由度未保持平衡，该描述仍然适用。然后推断出聚合物穿过孔的时间分布的一般特征。最后，我们考虑了更多的微观模型，并认为可用数据表明了一种易位机制，涉及聚合物主链与其他慢自由度之间的偶联。

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