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首页> 外文会议>NATO Advanced Research Workshop on Biological, Biophysical amp; Theoretical Aspects of Polymer Structure and Transport Jun 20-25, 1999 Bikal, Hungary >DYNAMIC PARTITIONING OF NEUTRAL POLYMERS INTO A SINGLE ION CHANNEL
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DYNAMIC PARTITIONING OF NEUTRAL POLYMERS INTO A SINGLE ION CHANNEL

机译：将中性聚合物动态分配成单离子通道

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摘要

Polymers partitioning into highly confined spaces can be studied using single nanometer-scale pores formed by protein ion channels. The ionic conductance of a channel depends on the state of occupancy of the pore by polymer and serves as a measure of polymer partitioning. Specifically, the movement of neutral polymer into the pore causes a reduction of the channel's conductance. The mean conductance is used to determine the polymer partition coefficient and the conductance fluctuations report the rates at which polymer exchanges between the bulk and the pore. Three theoretical approaches to describe the steric interaction of polymer and a single pore (hard spheres, random flight model, and scaling theory) fail to describe the partitioning of poly(ethylene glycol) into two structurally and chemically different ion channels (Staphylococcus aureus α-hemolysin and alamethicin). In particular, these theories cannot account for the sharp molecular weight dependence of the partition coefficient.
机译：可以使用由蛋白质离子通道形成的单个纳米级孔来研究划分为高度受限空间的聚合物。通道的离子电导率取决于聚合物对孔的占据状态，并用作聚合物分配的量度。具体而言，中性聚合物进入孔中会导致通道电导率降低。平均电导率用于确定聚合物分配系数，电导率波动报告了本体与孔之间聚合物交换的速率。三种描述聚合物与单个孔的空间相互作用的理论方法（硬球，随机飞行模型和缩放理论）未能描述聚乙二醇在两个结构和化学上不同的离子通道（金黄色葡萄球菌α-溶血素和阿乐美素）。特别地，这些理论不能解释分配系数对分子量的强烈依赖性。

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