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首页> 外文会议>NATO Advanced Research Workshop on Impact of Pollution on Animal Products; 20070927-30; Almaty(KZ) >ANALYTICAL MEASUREMENT AND LEVELS OF DIOXINS AND PCBs IN BIOLOGICAL SAMPLES
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ANALYTICAL MEASUREMENT AND LEVELS OF DIOXINS AND PCBs IN BIOLOGICAL SAMPLES

机译：生物样品中二恶英和多氯联苯的分析测量和水平

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摘要

Due to the high lipophilicity of dioxins are related compounds, more than 90% of the human exposure to dioxins is due to consumption of lipid-rich food such as meat; milk and dairies, as well as fish and derived products. The measurement of these trace level analytes requires a complex and tedious procedure including sample extraction, sample clean-up, and physico-chemical analysis after chromatographic separation. The determination of dioxins and related compounds requires a method that provides extremely high sensitivity and selectivity. High-resolution gas chromatography (HRGC) in combination with high-resolution mass spectrometry (HRMS) is the 'gold' standard method. In selected ion monitoring (SIM) mode, HRGC-HRMS (10,000 resolution) can achieve detection limit at the femtogram (10~(-15) g) level for most of the dioxin congeners. This paper explains the specificities and the pitfalls that could be met by analysts during the analytical development of this particular technique. Sample preparation, cleanup, selection of GC columns, specific aspects of double focusing sector instruments in SIM mode, high-resolution in mass, quantification by isotope dilution technique, quality assurance and quality control requirements and future perspectives are discussed and illustrated. A brief discussion of the bio-analytical approach is also provided to complete the analytical picture. Levels and trends for dioxins in food are discussed in the final part of the manuscript in the context of European regulation.
机译：由于二恶英是相关化合物的高亲脂性，超过90％的人接触二恶英是由于食用了富含脂质的食物（例如肉类）；牛奶和奶制品，以及鱼类和衍生产品。这些痕量分析物的测量需要复杂而繁琐的过程，包括样品提取，样品净化以及色谱分离后的理化分析。二恶英和相关化合物的测定需要一种提供极高灵敏度和选择性的方法。高分辨率气相色谱仪（HRGC）与高分辨率质谱仪（HRMS）相结合是“金”标准方法。在选定的离子监测（SIM）模式下，大多数二恶英同类物的HRGC-HRMS（10,000分辨率）可以达到飞克级（10〜（-15）g）的检测极限。本文解释了这种特定技术的分析开发过程中，分析人员可能会遇到的特殊性和陷阱。讨论并举例说明了样品制备，净化，GC色谱柱的选择，SIM模式下双聚焦扇形仪器的特定方面，质量的高分辨率，同位素稀释技术的定量，质量保证和质量控制要求以及未来的前景。还提供了对生物分析方法的简短讨论，以完成分析图。在本手册的最后部分中，在欧洲法规的背景下讨论了食品中二恶英的含量和趋势。

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