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首页> 外文会议>NATO Advanced Research Workshop on Impact of Pollution on Animal Products; 20070927-30; Almaty(KZ) >AFLATOXIN CONTAMINATION RISK: BIOACTIVE NATURAL COMPOUNDS FOR ANIMAL HEALTH AND HEALTHY FOOD
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AFLATOXIN CONTAMINATION RISK: BIOACTIVE NATURAL COMPOUNDS FOR ANIMAL HEALTH AND HEALTHY FOOD

机译：黄曲霉毒素污染风险：用于动物健康和健康食品的生物活性天然化合物

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摘要

Mycotoxin contamination is a worldwide problem and significant economic losses are associated with their impact on human health, animal productivity and both domestic and international trade. The FAO has estimated that up to 25% of the world's food crops and a higher percentage of the world's animal feedstuffs are significantly contaminated by mycotoxins and represent a human safety risk. Aflatoxin B_1 (AFB_1), a potentially lethal metabolite, is a known human carcinogen. AFB_1 is toxic to the liver, immunosuppressant, hepatocarcinogenic, teratogenic, and mutagenic. Aflatoxin carryover to animal products poses a health and economic liability and drives the demand for a method to prevent aflatoxin contamination of feedstuffs and/or animal food products such as milk, eggs, and meat. One of the innovative methods to overcome the toxic and carcinogenic effects of AFB_1 is to enhance its metabolism by natural substances reportedly possessing hepatoprotective effects. In this study we reported the effect of silymarin, a potent antihepatotoxic agent used as a hepatoprotector in man, on reducing aflatoxin M_1 (AFM_1) excretion in cows' milk and the effects of a silymarin in reducing the toxic effects of AFB_1 in broiler chickens.
机译：霉菌毒素污染是一个世界性的问题，严重的经济损失与其对人类健康，动物生产力以及国内外贸易的影响有关。粮农组织估计，多达25％的世界粮食作物和更高比例的世界动物饲料受到霉菌毒素的严重污染，对人类安全构成威胁。黄曲霉毒素B_1（AFB_1）是一种潜在的致命代谢物，是已知的人类致癌物。 AFB_1对肝脏，免疫抑制剂，肝癌致癌性，致畸性和致突变性有毒。黄曲霉毒素对动物产品的残留构成健康和经济责任，并驱使人们对防止饲料和/或动物食品（例如牛奶，鸡蛋和肉）中黄曲霉毒素污染的方法的需求。克服AFB_1的毒性和致癌作用的创新方法之一是通过据报道具有肝保护作用的天然物质增强其代谢。在这项研究中，我们报道了水飞蓟素（一种有效的抗肝毒性药物，可作为人的保肝剂）对减少牛奶中黄曲霉毒素M_1（AFM_1）排泄的作用，以及水飞蓟素对降低AFB_1对肉鸡的毒性作用的作用。

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