Protein-DNA recognition

机译：蛋白质-DNA识别

获取原文

获取原文并翻译 | 示例

页面导航

摘要
著录项
相似文献
相关主题

摘要

Understanding how proteins recognize DNA in a sequence-specific manner is central to understanding the regulation of transcription and other cellular processes. I will review the principles of DNA recognition that have emerged from the large number of high-resolution structures determined over the last 10 years. The DNA-binding domains of transcription factors exhibit surprisingly diverse protein architectures, yet all achieve a precise complemetarity of shape facilitating specific chemical recognition of their particular targets. Although general rules for recognition can be derived, the complex nature of the recognition mechanism precludes a simple recognition code. In particular, it has become evident that the structure and flexibility of DNA and contacts mediated by water molecules contribute to the recognition process. Based on the structural information it has proven possible to design proteins with novel recognition specificities. Despite this considerable practical success, the thermodynamic and kinetic properties of protein/DNA recognition remain poorly understood (reviewed in 1).

机译：了解蛋白质如何以序列特异性方式识别DNA是了解转录调控和其他细胞过程的关键。我将回顾过去十年来确定的大量高分辨率结构中出现的DNA识别原理。转录因子的DNA结合结构域展现出令人惊讶的多种蛋白质结构，但都实现了形状的精确互补，从而促进了对其特定靶标的特异性化学识别。尽管可以导出识别的一般规则，但是识别机制的复杂性排除了简单的识别代码。特别是，很明显，DNA的结构和柔韧性以及由水分子介导的接触有助于识别过程。基于结构信息，已证明设计具有新颖识别特异性的蛋白质是可能的。尽管取得了巨大的实践成功，但对蛋白质/ DNA识别的热力学和动力学特性仍然知之甚少（在1中进行了综述）。

著录项

来源
《NATO Advanced Research Workshop on RNA Biochemistry and Biotechnology Poznan, Poland October 10-17, 1998》|1998年|p.123-126|共4页
会议地点 Poznan(PL)
作者
Daniela Rhodes;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词

相似文献

外文文献
中文文献
专利

1. Optimization of Protein Thermostability and Exploitation of Recognition Behavior to Engineer Altered Protein-DNA Recognition [J] . Lambert Abigail R., Hallinan Jazmine P., Werther Rachel, Structure . 2020,第7期

机译：优化蛋白质热稳定性和识别行为的利用对工程师改变的蛋白质DNA识别
2. Sequence Correlations between Cro Recognition Helices and Cognate O(R) Consensus Half-sites Suggest Conserved Rules of Protein-DNA Recognition. [J] . Hall BM, Lefevre KR, Cordes MH Journal of Molecular Biology . 2005,第4期

机译：Cro识别螺旋和同源O（R）共识半位点之间的序列相关性提示蛋白质DNA识别的保守规则。
3. DNA mismatches reveal conformational penalties in protein-DNA recognition [J] . Ariel Afek, Honglue Shi, Atul Rangadurai, Nature . 2020,第7833期

机译：DNA不匹配揭示了蛋白质DNA识别中的构象性惩罚
4. Toward The Recognition Code Of Protein-DNA Recognition [C] . Juan Shan, Yuxuan Wang, Changhui Yan IEEE International Symposium on Bioinformatics and Bioengineering . 2007

机译：朝向蛋白质-DNA识别识别码
5. Complementarity in the structure and dynamics of protein-DNA search and recognition: A multiscale modeling study [D] . Hauser, Kevin Eduard. 2016

机译：蛋白质-DNA搜索和识别的结构和动力学的互补性：多尺度建模研究
6. Exploiting the recognition code for elucidating the mechanism of zinc finger protein-DNA interactions [O] . Shayoni Dutta, Spandan Madan, Durai Sundar 2016

机译：利用识别码阐明锌指蛋白-DNA相互作用的机理
7. Prediction pf Base Mulation Effects on Protein-DNA Recognition (IV) Anatomy of Specific Interactions in the Sequence Recognition by Lambda and Cro Repressors. [O] . M. Oobatake, H. Kono, Y. Wang, 1999

机译：λ和CRO阻遏物序列识别中蛋白质-DNA识别（iv）解剖学的基础突变效应预测。
8. Towards a Probabilistic Recognition Code for Protein-DNA Interactions: The PhageDisplay Approach [R] . Benos, P. V. 2000

机译：迈向蛋白质-DNa相互作用的概率识别代码：phageDisplay方法

Protein-DNA recognition

摘要

著录项

相似文献

相关主题

期刊订阅