Collagenase and Family: Targets for Drug Design

机译：胶原酶和家庭：药物设计的目标

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Collagenase belongs to a family of zinc and calcium dependent enzymes, the matrix metalloproteinases (MMPs), which are synthesised as zymogens in connective tissue. The MMPs, also called matrixins, represent viable targets for drug design since they have been implicated in the accelerated breakdown of connective tissue seen in pathological conditions such as arthritis, tumour metastasis and periodontal disease. Safe, effective and specific inhibitors of these proteases therefore provide potential as new treatments for a variety of diseases including cancer arthritis and multiple sclerosis.

机译：胶原酶属于锌和钙依赖性酶的一种，即基质金属蛋白酶（MMP），在结缔组织中合成为酶原。 MMP（也称为基质蛋白）代表了药物设计的可行目标，因为它们已牵涉到在诸如关节炎，肿瘤转移和牙周疾病等病理状况下看到的结缔组织加速分解。因此，这些蛋白酶的安全，有效和特异性抑制剂为治疗包括癌症关节炎和多发性硬化症在内的多种疾病提供了潜力。

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来源
《NATO Advanced Study Institute on Experimental and Computational Approaches to Structure-Based Drug Design May 9-19, 1996 Erice, Sicily, Italy》|1996年|p.77-85|共9页
会议地点 Erice(IT)
作者
N. Borkakoti; F. K. Winkler; D. H. Williams; A. DArcy;
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正文语种 eng
中图分类药学;
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Collagenase and Family: Targets for Drug Design

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